| Texto completo | |
| Autor(es): Mostrar menos - |
Grigoletto, Lais
[1, 2]
;
Brito, Luiz Fernando
[1]
;
Mattos, Elisangela C.
[2]
;
Eler, Joanir Pereira
[2]
;
Bussiman, Fernando Oliveira
[2]
;
Abreu Silva, Barbara da Conceicao
[2]
;
da Silva, Rosiane Pereira
[2]
;
Carvalho, Felipe Eguti
[2]
;
Berton, Mariana Piatto
[3]
;
Baldi, Fernando
[3]
;
Sterman Ferraz, Jose Bento
[2]
Número total de Autores: 11
|
| Afiliação do(s) autor(es): | [1] Purdue Univ, Dept Anim Sci, W Lafayette, IN 47907 - USA
[2] Univ Sao Paulo, Fac Zootecnia & Engn Alimentos, Dept Vet Med, Ave Duque de Caxias Norte 225, BR-13635900 Pirassununga, SP - Brazil
[3] Sao Paulo State Univ, Fac Ciencias Agr & Vet, Dept Anim Sci, Jaboticabal, SP - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | LIVESTOCK SCIENCE; v. 229, p. 64-76, NOV 2019. |
| Citações Web of Science: | 1 |
| Resumo | |
The Montana Tropical (R) Composite beef cattle have been developed in Brazil to serve as a genetic resource to meet the consumers' needs for higher-quality meat while animals are raised in extensive production systems under tropical conditions. In order to optimize the selection process for economically important traits in this population, various genetic and genomic studies are still lacking. In this regard, the aim of this study was to assess genetic parameters and identify genomic regions and potential candidate genes associated with various growth traits, using the single-step Genomic Best Linear Unbiased Predictor (ssGBLUP) method. Approximately 400,000 cows, bulls and progeny had measurements for birth weight (BW), weaning weight (WW), yearling weight (YW) and post-weaning weight gain (WG). A total of 1394 animals were genotyped for 27,199 SNPs (after the quality control) to enable implementation of weighted single-step genome-wide association studies. The traits included in this study were shown to be moderately heritable (i.e. heritability estimates ranging from 0.16 +/- 0.01 to 0.33 +/- 0.04) and the genetic correlations ranged from 0.60 +/- 0.067 (between WW and WG) to 0.88 +/- 0.08 (between BW and WW). Single-trait weighted genome-wide association studies enabled the identification of 83 genomic regions for direct genetic effects (all traits) and 29 genomic regions associated with maternal genetic effects on BW and WW traits. Furthermore, biological processes and pathways associated with survival to adult age, calf behavior, fatty acid metabolism, muscle development, fertility, and immune system were identified. The findings of this study greatly contribute to a better understanding of the genetic architecture of growth traits in the Montana Tropical (R) Composite population. Furthermore, the genomic regions identified can be given more importance (weight) when implementing genomic selection for these traits, by using weighted ssGBLUP or Bayesian approaches. (AU) | |
| Processo FAPESP: | 17/11919-6 - Aplicação de estratégias de estudos genômicos para características produtivas em bovinos Montana Composto Tropical® |
| Beneficiário: | Laís Grigoletto |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 18/20393-0 - Otimização do desempenho de produção em bovinos de corte compostos através do uso de abordagens genômicas alternativas |
| Beneficiário: | Laís Grigoletto |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado |
| Processo FAPESP: | 14/07566-2 - Genômica aplicada à produção de ruminantes |
| Beneficiário: | José Bento Sterman Ferraz |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |