Mechanisms of Photosensitized Lipid Oxidation and Membrane Permeabilization

Autor(es)

Bacellar, Isabel O. L. ^{[1, 2]} ; Baptista, Mauricio S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, Ave Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP - Brazil

^[2] Univ Montreal, Dept Biochim, CF 6128, Succursale Ctr Ville, Montreal, PQ H3C 3J7 - Canada

• Tipo de documento: Artigo de Revisão
• Fonte: ACS OMEGA; v. 4, n. 26, p. 21636-21646, DEC 24 2019.
• Citações Web of Science: 0

Resumo

Lipid oxidation encompasses chemical transformations affecting animals and plants in many ways, and light is one of the most common triggers of lipid oxidation in our habitat. Still, the molecular mechanisms and biological consequences of photoinduced lipid oxidation were only recently understood at the molecular level. In this review, we focus on the main mechanisms of photosensitized lipid oxidation and membrane permeabilization, dissecting the consequences of both singlet oxygen and contact-dependent pathways and discussing how these reactions contribute to chemical and biophysical changes in lipid membranes. We aim to enable scientists to develop novel and more efficient photosensitizers in photomedicine, as well as better strategies for sun protection. (AU)

• Processo FAPESP: 13/07937-8 - Redoxoma
• Beneficiário: Ohara Augusto
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 13/11640-0 - Relação entre o dano fotoinduzido em lipídeos e a permeabilização de membranas
• Beneficiário: Isabel de Oliveira Lima Bacellar
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto