Mechanisms of Photosensitized Lipid Oxidation and Membrane Permeabilization

Author(s)

Bacellar, Isabel O. L. ^{[1, 2]} ; Baptista, Mauricio S. ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, Ave Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP - Brazil

^[2] Univ Montreal, Dept Biochim, CF 6128, Succursale Ctr Ville, Montreal, PQ H3C 3J7 - Canada

• Document type: Review article
• Source: ACS OMEGA; v. 4, n. 26, p. 21636-21646, DEC 24 2019.
• Web of Science Citations: 0

Abstract

Lipid oxidation encompasses chemical transformations affecting animals and plants in many ways, and light is one of the most common triggers of lipid oxidation in our habitat. Still, the molecular mechanisms and biological consequences of photoinduced lipid oxidation were only recently understood at the molecular level. In this review, we focus on the main mechanisms of photosensitized lipid oxidation and membrane permeabilization, dissecting the consequences of both singlet oxygen and contact-dependent pathways and discussing how these reactions contribute to chemical and biophysical changes in lipid membranes. We aim to enable scientists to develop novel and more efficient photosensitizers in photomedicine, as well as better strategies for sun protection. (AU)

• FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
• Grantee: Ohara Augusto
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 13/11640-0 - Relationship between the photoinduced damage in lipids and membrane permeabilization
• Grantee: Isabel de Oliveira Lima Bacellar
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)