Mechanochemistry for the production of a hybrid salt used in the treatment of malaria

Autor(es)

do Prado, Vania M. ^[1] ; de Queiroz, Thiago B. ^[1] ; Sa, Paula M. ^[2] ; Seiceira, Rafael C. ^[3] ; Boechat, Nubia ^[2] ; Ferreira, Fabio F. ^[1]

Afiliação do(s) autor(es)

^[1] Fed Univ ABC UFABC, Ctr Nat & Human Sci CCNH, Av Estados 5001, BR-09210580 Santo Andre, SP - Brazil

^[2] Farmanguinhos Fiocruz, Dept Drug Synth, Av Comandante Guarany 447, BR-22775903 Rio De Janeiro, RJ - Brazil

^[3] Farmanguinhos Fiocruz, Lab Solid State Studies LEES, Av Comandante Guarany 447, BR-22775903 Rio De Janeiro, RJ - Brazil

• Tipo de documento: Artigo Científico
• Fonte: GREEN CHEMISTRY; v. 22, n. 1, p. 54-61, JAN 7 2020.
• Citações Web of Science: 0

Resumo

Mechanochemistry refers to a chemical reaction induced by mechanical energy involving solids. This method provides several advantages over solution-phase synthesis, such as minimizing the need for large volumes of solvents in chemical reactions and greener and more efficient synthetic solutions. In this paper we obtain, via mechanochemistry, a hybrid salt, named MEFAS, derived from two antimalarial molecules - mefloquine and artesunate. We demonstrate, using a simple experimental procedure, how the catalytic amount of liquid present during mechanochemical reactions is decisive to obtain MEFAS. Fourier-transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) data indicate that liquid-assisted mechanochemical reactions are promising in the formation of the hybrid salt, which is formed via a hydrogen interaction of the carboxylate group of the artesunate molecule with the piperidine group of mefloquine. (AU)

• Processo FAPESP: 15/26233-7 - Síntese e caracterização estrutural de cocristais para aplicações em protetores solares e antioxidantes de uso tópico
• Beneficiário: Fabio Furlan Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Regular