| Full text | |
| Author(s): |
do Prado, Vania M.
[1]
;
de Queiroz, Thiago B.
[1]
;
Sa, Paula M.
[2]
;
Seiceira, Rafael C.
[3]
;
Boechat, Nubia
[2]
;
Ferreira, Fabio F.
[1]
Total Authors: 6
|
| Affiliation: | [1] Fed Univ ABC UFABC, Ctr Nat & Human Sci CCNH, Av Estados 5001, BR-09210580 Santo Andre, SP - Brazil
[2] Farmanguinhos Fiocruz, Dept Drug Synth, Av Comandante Guarany 447, BR-22775903 Rio De Janeiro, RJ - Brazil
[3] Farmanguinhos Fiocruz, Lab Solid State Studies LEES, Av Comandante Guarany 447, BR-22775903 Rio De Janeiro, RJ - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | GREEN CHEMISTRY; v. 22, n. 1, p. 54-61, JAN 7 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Mechanochemistry refers to a chemical reaction induced by mechanical energy involving solids. This method provides several advantages over solution-phase synthesis, such as minimizing the need for large volumes of solvents in chemical reactions and greener and more efficient synthetic solutions. In this paper we obtain, via mechanochemistry, a hybrid salt, named MEFAS, derived from two antimalarial molecules - mefloquine and artesunate. We demonstrate, using a simple experimental procedure, how the catalytic amount of liquid present during mechanochemical reactions is decisive to obtain MEFAS. Fourier-transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) data indicate that liquid-assisted mechanochemical reactions are promising in the formation of the hybrid salt, which is formed via a hydrogen interaction of the carboxylate group of the artesunate molecule with the piperidine group of mefloquine. (AU) | |
| FAPESP's process: | 15/26233-7 - Synthesis and structural characterization of cocrystals for application as sunscreen and antioxidants of topical use |
| Grantee: | Fabio Furlan Ferreira |
| Support Opportunities: | Regular Research Grants |