Synthesis, characterization and uses of metal complexes for prevention, diagnosis and treatment of diseases, mainly neglected diseases.

• Grant number: 17/11570-3
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2017
• End date: November 30, 2019
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Antonio Carlos Massabni
• Grantee: Antonio Carlos Massabni
• Host Institution: Universidade de Araraquara (UNIARA). Associação São Bento de Ensino. Araraquara , SP, Brazil
• Associated researchers: Eliane Trovatti ; Flávia Aparecida Resende Nogueira

Abstract

SUMMARYThe present Project deals with synthesis, characterization and uses of metal complexes for prevention, diagnosis and treatment of diseases, mainly the neglected diseases. Ligands like carboxylic acids and derivatives (aminoacids and ±-hydroxycarboxylic acids), amino-quinolines and derivatives, natural substances, sweetings and organic pharmaceutical drugs, which have been used for treatment of illness. The ligands will be used for treatment of illness. The ligands will be used as the anionic form or modified according to the convenience. Metal salts of Cu(II),Zn(II), Ag(I), Au(I) or (III), Pt(II), V(IV), Ti(IV) and Mo(IV) or (VI) will be also used. Choice of the metal ions will depend of the type of ligand, the selected disease and the characteristic of coordination of the ligands and the metal salts. The complexes will be characterized by elemental analysis, IR, UV-vis and NMR spectroscopic techniques, thermogravimetric analysis, X-ray diffraction and others which will be necessary.The complexes will be used in solution to test their biological activities. The complexes which had showed activity will be studied to verify the mutagenicity and the mecanisms of action. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PARIS JUNIOR, JOSE ALBERTO; CAVICCHIOLI, MAURICIO; AMARAL MACHADO, RACHEL TEMPERANI; PAVAN, FERNANDO; NAKAHATA, DOUGLAS HIDEKI; CORBI, PEDRO PAULO; FERREIRA COSTA, ADAO MARCOS; PEREIRA, DOUGLAS HENRIQUE; MASSABNI, ANTONIO CARLOS. SYNTHESIS, CHARACTERIZATION, DFT MODELING AND IN VITRO ANTIMYCOBACTERIAL ACTIVITY ASSAYS OF A SILVER(I)-ISONIAZID COMPLEX. Química Nova, v. 44, n. 3, p. 278-283, 2021. (13/08293-7, 15/20882-3, 17/11570-3, 17/11485-6, 18/12062-4)