Synthesis, characterization and pharmacological studies of Ag(I), Au(I), Pt(II) and Pd(II) complexes with bioactive ligands

• Grant number: 12/08230-2
• Support Opportunities: Regular Research Grants
• Duration: August 01, 2012 - July 31, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Pedro Paulo Corbi
• Grantee: Pedro Paulo Corbi
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Metal complexes have been used worldwide in medicine for diagnosis and treatment of various diseases. Inorganic compounds and their medical applications include, for example, treatment of cancer and arthritis, antimicrobial agents and enzyme inhibitors. The structural knowledge and understanding of the mechanisms of pharmacological action of these compounds are of fundamental importance in the development of safer and more efficient drugs.Currently, gold complexes are used in the treatment of arthritis, silver complexes in the treatment of bacterial infections and platinum complexes in cancer treatment. In addition, new metal complexes of palladium(II), ruthenium(II), ruthenium(III) and gold(I) have been synthesized and described as potential antimicrobial and antitumor agents. This project deals with the preparation, characterization and pharmacological application of new metal complexes of platinum(II), palladium(II), gold(I) and silver(I) with nimesulide, cycloserine, butionine sulfoximine and rimantadine in the treatment of diseases such as cancer and bacterial infections. (AU)

Scientific publications

(19)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CARVALHO, MARCOS A.; SHISHIDO, SILVIA M.; SOUZA, BARBARA C.; DE PAIVA, RAPHAEL E. F.; GOMES, ALEXANDRE F.; GOZZO, FABIO C.; FORMIGA, ANDRE L. B.; CORBI, PEDRO P.. A new platinum complex with tryptophan: Synthesis, structural characterization, DFT studies and biological assays in vitro over human tumorigenic cells. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 122, p. 209-215, MAR 25 2014. (12/08230-2)

PAIVA, ISABELA L.; DE CARVALHO, GUSTAVO S. G.; DA SILVA, ADILSON D.; CORBI, PEDRO P.; BERGAMINI, FERNANDO R. G.; FORMIGA, ANDRE L. B.; DINIZ, RENATA; DO CARMO, WEBERTON R.; LEITE, CLARICE Q. F.; PAVAN, FERNANDO R.; et al. Silver(I) complexes with symmetrical Schiff bases: Synthesis, structural characterization, DFT studies and antimycobacterial assays. Polyhedron, v. 62, p. 104-109, OCT 7 2013. (11/11593-7, 09/06499-1, 12/08230-2)

CARVALHO, MARCOS A.; DE PAIVA, RAPHAEL E. F.; BERGAMINI, FERNANDO R. G.; GOMES, ALEXANDRE F.; GOZZO, FABIO C.; LUSTRI, WILTON R.; FORMIGA, ANDRE L. B.; SHISHIDO, SILVIA M.; FERREIRA, CARMEN V.; CORBI, PEDRO P.. A silver complex with tryptophan: Synthesis, structural characterization, DFT studies and antibacterial and antitumor assays in vitro. Journal of Molecular Structure, v. 1031, p. 125-131, JAN 16 2013. (08/57805-2, 12/08230-2)

LUSTRI, WILTON R.; LAZARINI, SILMARA C.; LUSTRI, BRUNA CARDINALI; CORBI, PEDRO P.; SILVA, MARIA ALINE C.; RESENDE NOGUEIRA, FLAVIA APARECIDA; AQUINO, RENATA; AMARAL, ANDRE C.; TREU FILHO, OSWALDO; MASSABNI, ANTONIO CARLOS; et al. Spectroscopic characterization and biological studies in vitro of a new silver complex with furosemide: Prospective of application as an antimicrobial agent. Journal of Molecular Structure, v. 1134, p. 386-394, APR 15 2017. (15/09833-0, 15/25114-4, 12/08230-2)

ZANVETTOR, NINA T.; NAKAHATA, DOUGLAS H.; DE PAIVA, RAPHAEL E. F.; RIBEIRO, MARCOS A.; CUIN, ALEXANDRE; CORBI, PEDRO P.; FORMIGA, ANDRE L. B.. Copper(II), palladium(II) and platinum(II) complexes with 2,2-thiophen-yl-imidazole: Synthesis, spectroscopic characterization, X-ray crystallographic studies and interactions with calf-thymus DNA. Inorganica Chimica Acta, v. 443, p. 304-315, MAR 24 2016. (12/08230-2)

ZANVETTOR, NINA T.; ABBEHAUSEN, CAMILLA; LUSTRI, WILTON R.; CUIN, ALEXANDRE; MASCIOCCHI, NORBERTO; CORBI, PEDRO P.. Silver sulfadoxinate: Synthesis, structural and spectroscopic characterizations, and preliminary antibacterial assays in vitro. Journal of Molecular Structure, v. 1082, p. 180-187, FEB 15 2015. (11/02452-0, 12/08230-2)

DE PAIVA, RAPHAEL E. F.; ABBEHAUSEN, CAMILLA; BERGAMINI, FERNANDO R. G.; THOMPSON, ANDRE L.; ALVES, DANILO A.; LANCELLOTTI, MARCELO; CORBI, PEDRO P.. Investigating the inclusion of the Ag(I)-nimesulide complex into beta-cyclodextrin: studies in solution and in the solid state. JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, v. 79, n. 1-2, p. 11-pg., 2014-06-01. (12/08230-2)

DE PAIVA, RAPHAEL E. F.; ABBEHAUSEN, CAMILLA; BERGAMINI, FERNANDO R. G.; THOMPSON, ANDRE L.; ALVES, DANILO A.; LANCELLOTTI, MARCELO; CORBI, PEDRO P.. Investigating the inclusion of the Ag(I)-nimesulide complex into beta-cyclodextrin: studies in solution and in the solid state. Journal of Inclusion Phenomena and Macrocyclic Chemistry, v. 79, n. 1-2, p. 225-235, JUN 2014. (12/08230-2)

DE CARVALHO, MARCOS ALBERTO; ANDRADE, PATRICIA FERNANDA; ANDRADE CORBI, FABIANA CRISTINA; GONCALVES, MARIA DO CARMO; FORMIGA, ANDRE LUIZ BARBOZA; MAZALI, ITALO ODONE; BONACIN, JULIANO ALVES; CORBI, PEDRO PAULO. A simple method to synthesize fluorescent modified gold nanoparticles using tryptamine as the reducing and capping agent. Synthetic Metals, v. 185, p. 61-65, DEC 1 2013. (12/08230-2)

GOULART BERGAMINI, FERNANDO RODRIGUES; FERREIRA, JR., MARCOS ANTONIO; FERRAZ DE PAIVA, RAPHAEL ENOQUE; GOMES, ALEXANDRE FERREIRA; GOZZO, FABIO CESAR; BARBOZA FORMIGA, ANDRE LUIZ; ANDRADE CORBI, FABIANA CRISTINA; MAZALI, ITALO ODONE; ALVES, DANILO ANTONINI; LANCELLOTTI, MARCELO; et al. A binuclear silver complex with L-buthionine sulfoximine: synthesis, spectroscopic characterization, DFT studies and antibacterial assays. RSC ADVANCES, v. 2, n. 27, p. 10372-10379, 2012. (08/57805-2, 12/08230-2)

ABBEHAUSEN, CAMILLA; SUCENA, SUELEN F.; LANCELLOTTI, MARCELO; HEINRICH, TASSIELE A.; ABRAO, EMILIANA P.; COSTA-NETO, CLAUDIO M.; FORMIGA, ANDRE L. B.; CORBI, PEDRO P.. Synthesis, spectroscopic characterization, DFT studies, and antibacterial and antitumor activities of a novel water soluble Pd(II) complex with L-alliin. Journal of Molecular Structure, v. 1035, p. 421-426, MAR 13 2013. (12/08230-2)

PEREIRA E SILVA, IRLENE MARIA; PROFIRIO, DANIEL DE MORAES; FERRAZ DE PAIVA, RAPHAEL ENOQUE; LANCELLOTTI, MARCELO; BARBOZA FORMIGA, ANDRE LUIZ; CORBI, PEDRO PAULO. A silver complex with ibuprofen: Synthesis, solid state characterization, DFT calculations and antibacterial assays. Journal of Molecular Structure, v. 1049, p. 1-6, OCT 8 2013. (12/08230-2)

LAZARINI, SILMARA C.; DE AQUINO, RENATA; AMARAL, ANDRE C.; CORBI, FABIANA C. A.; CORBI, PEDRO P.; BARUD, HERNANE S.; LUSTRI, WILTON R.. Characterization of bilayer bacterial cellulose membranes with different fiber densities: a promising system for controlled release of the antibiotic ceftriaxone. Cellulose, v. 23, n. 1, p. 737-748, FEB 2016. (12/08230-2)

BORMIO NUNES, JULIA HELENA; FERRAZ DE PAIVA, RAPHAEL ENOQUE; CUIN, ALEXANDRE; DA COSTA FERREIRA, ANA MARIA; LUSTRI, WILTON ROGERIO; CORBI, PEDRO PAULO. Synthesis, spectroscopic characterization, crystallographic studies and antibacterial assays of new copper(II) complexes with sulfathiazole and nimesulide. Journal of Molecular Structure, v. 1112, p. 14-20, MAY 15 2016. (12/08230-2)

CARVALHO, MARCOS A.; ARRUDA, EDUARDO G. R.; PROFIRIO, DANIEL M.; GOMES, ALEXANDRE F.; GOZZO, FABIO C.; FORMIGA, ANDRE L. B.; CORBI, PEDRO P.. Chemical and spectroscopic characterizations, ESI-QTOF mass spectrometric measurements and DFT studies of new complexes of palladium(II) with tryptamine and mefenamic acid. Journal of Molecular Structure, v. 1100, p. 6-13, NOV 15 2015. (12/08230-2)

PROFIRIO, DANIEL DE MORAES; FERRAZ DE PAIVA, RAPHAEL ENOQUE; ABBEHAUSEN, CAMILLA; CUIN, ALEXANDRE; MASCIOCCHI, NORBERTO; MACHADO, DAISY; LANCELLOTTI, MARCELO; CORBI, PEDRO PAULO; BARBOZA FORMIGA, ANDRE LUIZ. Crystal structure and cytotoxic activities of a bis(pyrrolyl-imine) gold(III) complex. Journal of Coordination Chemistry, v. 69, n. 18, p. 2707-2722, 2016. (12/08230-2)

BORMIO NUNES, JULIA HELENA; FERRAZ DE PAIVA, RAPHAEL ENOQUE; CUIN, ALEXANDRE; LUSTRI, WILTON ROGERIO; CORBI, PEDRO PAULO. Silver complexes with sulfathiazole and sulfamethoxazole: Synthesis, spectroscopic characterization, crystal structure and antibacterial assays. Polyhedron, v. 85, p. 437-444, JAN 8 2015. (12/08230-2)

BERGAMINI, F. R. G.; RIBEIRO, M. A.; LANCELLOTTI, M.; MACHADO, D.; MIRANDA, P. C. M. L.; CUIN, A.; FORMIGA, A. L. B.; CORBI, P. P.. Synthesis, spectroscopic characterizations, crystal structures and DFT studies of nalidixic acid carbonyl hydrazones derivatives. Journal of Molecular Structure, v. 1120, p. 115-124, SEP 15 2016. (12/08230-2)

AMARAL, THAENY C.; DE CARVALHO, GUSTAVO S. G.; DA SILVA, ADILSON D.; CORBI, PEDRO P.; MASCIOCCHI, NORBERTO; CASTELLANO, EDUARDO E.; CUIN, ALEXANDRE. Three new mononuclear group 12 complexes with benzimidazole. Journal of Coordination Chemistry, v. 67, n. 8, p. 1380-1391, 2014. (12/08230-2)