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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Fabrication of Biocompatible Composites of Poly(lactic acid)/Hydroxyapatite Envisioning Medical Applications

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Autor(es):
Backes, Eduardo Henrique [1] ; Pires, Lais De Nobile [2] ; Beatrice, Cesar Augusto Goncalves [2] ; Costa, Lidiane Cristina [2] ; Passador, Fabio Roberto [3] ; Pessan, Luiz Antonio [2]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Fed Sao Carlos, Grad Program Mat Sci & Engn, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Mat Engn, BR-13565905 Sao Carlos, SP - Brazil
[3] Univ Fed Sao Paulo, Inst Sci & Technol, BR-12231280 Sao Jose Dos Campos, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: POLYMER ENGINEERING AND SCIENCE; v. 60, n. 3 JAN 2020.
Citações Web of Science: 0
Resumo

Over the last years, orthopedic procedures for bone repairs have been developed due to an increase in trauma and diseases. The development of bioactive composites using biodegradable polymers like poly(lactic acid) (PLA) and bioactive fillers as hydroxyapatite (HA) originate biomaterials, which combine bioactivity of HA and PLA biocompatibility. Therefore, using additive manufacturing is possible for the production of customized products made from these materials; however, a thorough study of these materials is required. In this context, melt-compounding has been used to manufacture bioactive composites of PLA/HA, and rheological, molecular, and thermomechanical behavior were assessed. The biocomposite of PLA with 10 wt% HA presented a strong shear thinning behavior, which makes it more suitable for fused filament fabrication since lower printing pressure is required. Furthermore, this composite presented an enhancement of 12% in thermomechanical properties in comparison to PLA and a slight increase in cell proliferation. PLA and PLA/HA were fabricated and used to produce 3D calibrations cube as a proof of concept. They presented good printability and high accuracy, and therefore, further investigation needs to be performed to unleash its use in bone tissue engineering applications. POLYM. ENG. SCI., 2020. (c) 2020 Society of Plastics Engineers (AU)

Processo FAPESP: 17/09609-9 - Desenvolvimento de scaffolds bioinspirados de PLA/cargas cerâmicas bioativas via impressão 3D
Beneficiário:Luiz Antonio Pessan
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 17/11366-7 - Desenvolvimento de scaffolds bioinspirados de PLA/biovidros via impressão 3D
Beneficiário:Eduardo Henrique Backes
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 16/19978-9 - Desenvolvimento de nanocompósitos de blendas de PA6/LLDPE e negro de fumo para embalagens antiestáticas para componentes eletrônicos
Beneficiário:Fabio Roberto Passador
Linha de fomento: Auxílio à Pesquisa - Regular