Fabrication of Biocompatible Composites of Poly(lactic acid)/Hydroxyapatite Envisioning Medical Applications

Autor(es)

Backes, Eduardo Henrique ^[1] ; Pires, Lais De Nobile ^[2] ; Beatrice, Cesar Augusto Goncalves ^[2] ; Costa, Lidiane Cristina ^[2] ; Passador, Fabio Roberto ^[3] ; Pessan, Luiz Antonio ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Grad Program Mat Sci & Engn, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Mat Engn, BR-13565905 Sao Carlos, SP - Brazil

^[3] Univ Fed Sao Paulo, Inst Sci & Technol, BR-12231280 Sao Jose Dos Campos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: POLYMER ENGINEERING AND SCIENCE; v. 60, n. 3 JAN 2020.
• Citações Web of Science: 0

Resumo

Over the last years, orthopedic procedures for bone repairs have been developed due to an increase in trauma and diseases. The development of bioactive composites using biodegradable polymers like poly(lactic acid) (PLA) and bioactive fillers as hydroxyapatite (HA) originate biomaterials, which combine bioactivity of HA and PLA biocompatibility. Therefore, using additive manufacturing is possible for the production of customized products made from these materials; however, a thorough study of these materials is required. In this context, melt-compounding has been used to manufacture bioactive composites of PLA/HA, and rheological, molecular, and thermomechanical behavior were assessed. The biocomposite of PLA with 10 wt% HA presented a strong shear thinning behavior, which makes it more suitable for fused filament fabrication since lower printing pressure is required. Furthermore, this composite presented an enhancement of 12% in thermomechanical properties in comparison to PLA and a slight increase in cell proliferation. PLA and PLA/HA were fabricated and used to produce 3D calibrations cube as a proof of concept. They presented good printability and high accuracy, and therefore, further investigation needs to be performed to unleash its use in bone tissue engineering applications. POLYM. ENG. SCI., 2020. (c) 2020 Society of Plastics Engineers (AU)

• Processo FAPESP: 17/09609-9 - Desenvolvimento de scaffolds bioinspirados de PLA/cargas cerâmicas bioativas via impressão 3D
• Beneficiário: Luiz Antonio Pessan
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/11366-7 - Desenvolvimento de scaffolds bioinspirados de PLA/biovidros via impressão 3D
• Beneficiário: Eduardo Henrique Backes
• Linha de fomento: Bolsas no Brasil - Doutorado
• Processo FAPESP: 16/19978-9 - Desenvolvimento de nanocompósitos de blendas de PA6/LLDPE e negro de fumo para embalagens antiestáticas para componentes eletrônicos
• Beneficiário: Fabio Roberto Passador
• Linha de fomento: Auxílio à Pesquisa - Regular