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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Fabrication of Biocompatible Composites of Poly(lactic acid)/Hydroxyapatite Envisioning Medical Applications

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Backes, Eduardo Henrique [1] ; Pires, Lais De Nobile [2] ; Beatrice, Cesar Augusto Goncalves [2] ; Costa, Lidiane Cristina [2] ; Passador, Fabio Roberto [3] ; Pessan, Luiz Antonio [2]
Total Authors: 6
[1] Univ Fed Sao Carlos, Grad Program Mat Sci & Engn, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Mat Engn, BR-13565905 Sao Carlos, SP - Brazil
[3] Univ Fed Sao Paulo, Inst Sci & Technol, BR-12231280 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 1

Over the last years, orthopedic procedures for bone repairs have been developed due to an increase in trauma and diseases. The development of bioactive composites using biodegradable polymers like poly(lactic acid) (PLA) and bioactive fillers as hydroxyapatite (HA) originate biomaterials, which combine bioactivity of HA and PLA biocompatibility. Therefore, using additive manufacturing is possible for the production of customized products made from these materials; however, a thorough study of these materials is required. In this context, melt-compounding has been used to manufacture bioactive composites of PLA/HA, and rheological, molecular, and thermomechanical behavior were assessed. The biocomposite of PLA with 10 wt% HA presented a strong shear thinning behavior, which makes it more suitable for fused filament fabrication since lower printing pressure is required. Furthermore, this composite presented an enhancement of 12% in thermomechanical properties in comparison to PLA and a slight increase in cell proliferation. PLA and PLA/HA were fabricated and used to produce 3D calibrations cube as a proof of concept. They presented good printability and high accuracy, and therefore, further investigation needs to be performed to unleash its use in bone tissue engineering applications. POLYM. ENG. SCI., 2020. (c) 2020 Society of Plastics Engineers (AU)

FAPESP's process: 16/19978-9 - Development of PA6/LLDPE blend-based carbon black nanocomposites for antistatic packaging for electronic components
Grantee:Fabio Roberto Passador
Support type: Regular Research Grants
FAPESP's process: 17/09609-9 - Development of bioinspired scaffolds of PLA/bioactive ceramic fillers through 3D printing
Grantee:Luiz Antonio Pessan
Support type: Regular Research Grants
FAPESP's process: 17/11366-7 - Development of bio-inspired PLA/bioglass scaffolds via 3D printed
Grantee:Eduardo Henrique Backes
Support type: Scholarships in Brazil - Doctorate