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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Polyurethane fibrous membranes tailored by rotary jet spinning for tissue engineering applications

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Autor(es):
Pereira Rodrigues, Isabella Caroline [1] ; Tamborlin, Leticia [2, 1] ; Rodrigues, Ana Amelia [3] ; Jardini, Andre Luiz [4, 5] ; Luchessi, Augusto Ducati [2, 1] ; Maciel Filho, Rubens [4, 5] ; Najar Lopes, Eder Socrates [6] ; Gabriel, Lais Pellizzer [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Sch Appl Sci, Limeira, SP - Brazil
[2] Sao Paulo State Univ, Inst Biosci, Rio Claro, SP - Brazil
[3] Univ Estadual Campinas, Sch Med Sci, Campinas, SP - Brazil
[4] Univ Estadual Campinas, Sch Chem Engn, Campinas, SP - Brazil
[5] Natl Inst Biofabricat, Campinas, SP - Brazil
[6] Univ Estadual Campinas, Sch Mech Engn, Campinas, SP - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: Journal of Applied Polymer Science; SEP 2019.
Citações Web of Science: 0
Resumo

Polymeric membranes have gained popularity as fibrous structures for tissue regeneration. This research focuses on the rotary jet spinning (RJS) process combined with a polymer as a strategy for designing membranes. To this end, RJS-polyurethane (RJS-PU) membranes with different microstructures were produced. Considering the effects of solution properties on fiber production, the viscosity of PU solutions was evaluated. Membrane morphology was studied based on scanning electron microscopy and 2D fast Fourier transform analysis. The chemical and thermal properties were characterized by Fourier-transform infrared spectroscopy and thermogravimetric analysis, respectively. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and Live/Dead cell assays were performed to determine the material cytotoxicity by assessment of the profile of proliferation and cell viability. The results indicated that the combination of PU and RJS was an effective one for the production of fibrous structures for tissue engineering applications, demonstrating good compatibility with the cultured osteoblastic cell line. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48455. (AU)

Processo FAPESP: 08/57860-3 - BIOFABRIS - Instituto de Biofabricação
Beneficiário:Rubens Maciel Filho
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 17/13273-6 - Desenvolvimento de scaffolds tubulares para aplicações na engenharia de tecidos vascular
Beneficiário:Laís Pellizzer Gabriel
Linha de fomento: Auxílio à Pesquisa - Regular