Polyurethane fibrous membranes tailored by rotary jet spinning for tissue engineering applications

Author(s)

Pereira Rodrigues, Isabella Caroline ^[1] ; Tamborlin, Leticia ^{[2, 1]} ; Rodrigues, Ana Amelia ^[3] ; Jardini, Andre Luiz ^{[4, 5]} ; Luchessi, Augusto Ducati ^{[2, 1]} ; Maciel Filho, Rubens ^{[4, 5]} ; Najar Lopes, Eder Socrates ^[6] ; Gabriel, Lais Pellizzer ^[1]

Affiliation

^[1] Univ Estadual Campinas, Sch Appl Sci, Limeira, SP - Brazil

^[2] Sao Paulo State Univ, Inst Biosci, Rio Claro, SP - Brazil

^[3] Univ Estadual Campinas, Sch Med Sci, Campinas, SP - Brazil

^[4] Univ Estadual Campinas, Sch Chem Engn, Campinas, SP - Brazil

^[5] Natl Inst Biofabricat, Campinas, SP - Brazil

^[6] Univ Estadual Campinas, Sch Mech Engn, Campinas, SP - Brazil

• Document type: Journal article
• Source: Journal of Applied Polymer Science; SEP 2019.
• Web of Science Citations: 0

Abstract

Polymeric membranes have gained popularity as fibrous structures for tissue regeneration. This research focuses on the rotary jet spinning (RJS) process combined with a polymer as a strategy for designing membranes. To this end, RJS-polyurethane (RJS-PU) membranes with different microstructures were produced. Considering the effects of solution properties on fiber production, the viscosity of PU solutions was evaluated. Membrane morphology was studied based on scanning electron microscopy and 2D fast Fourier transform analysis. The chemical and thermal properties were characterized by Fourier-transform infrared spectroscopy and thermogravimetric analysis, respectively. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and Live/Dead cell assays were performed to determine the material cytotoxicity by assessment of the profile of proliferation and cell viability. The results indicated that the combination of PU and RJS was an effective one for the production of fibrous structures for tissue engineering applications, demonstrating good compatibility with the cultured osteoblastic cell line. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48455. (AU)

• FAPESP's process: 17/13273-6 - Development of tubular scaffolds for applications in vascular tissue engineering
• Grantee: Laís Pellizzer Gabriel
• Support Opportunities: Regular Research Grants