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Development of bioactive bioinks and production of bioabsorbable custom scaffolds by additive manufacturing and rotary jet spinning to bone tissue repair

Abstract

The development of customized bioabsorbable implants for the treatment of bone injuries due to the possibility of producing designed implants according to the specificity of each patient's injury is notorious in the health area. The production of customized bioabsorbable implants by additive manufacturing (AM) is a technology that may represent numerous advantages in view of the difficulties encountered in current procedures related to implant geometry, surgical planning, product quality, adaptation and fixation of the implant and the easy recovery in the post-operative period. The main bioabsorbable materials studied as implants for bone repairs are those of polymeric matrix and designed based on tissue engineering techniques. An interesting strategy is to cover the three-dimensional implants with rotary jet spun membranes containing drugs, in order to promote antibacterial properties. The scope of this research project is to produce customized implants to act as scaffolds, based on a polymeric bioabsorbable matrix with osteoconductive and antibacterial properties, to promote the bone repair. For this, the first stage of this project consists of the development of bioinks containing osteoconductive ceramic particles for later printing. Bioinks will be developed based on the bioabsorbable polymer poly (lactic-co-glycolic acid) (PLGA) doped with hydroxyapatite. After development, three-dimensional matrices will be printed by MA using the developed bioink in different concentrations and geometries. Finally, the three-dimensional matrices will be covered with a PLGA membrane in a controlled release system containing the drug rifampicin produced by rotary jet spinning technique. The scaffolds will be characterized in terms of morphological, chemical, thermal, mechanical and biological properties, according to ASTM F2150. At the end of the project, it is expected to have the domain in the development of bioactive bioinks and the production and commercialization of customized implants for bone reconstructions, which will ultimately reduce the rehabilitation time thus providing a better quality of life to the patient. This project will be developed at the Polymer Science and Technology Laboratory (LPol) of the School of Applied Sciences at UNICAMP and will make use of the rotary jet spinning equipment obtained in the project FAPESP 2017 / 13273-6. (AU)