Advanced search
Start date
Betweenand

Development of tubular scaffolds for applications in vascular tissue engineering

Grant number: 17/13273-6
Support type:Regular Research Grants
Duration: November 01, 2017 - April 30, 2020
Field of knowledge:Engineering - Chemical Engineering - Chemical Technology
Principal Investigator:Laís Pellizzer Gabriel
Grantee:Laís Pellizzer Gabriel
Home Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
Assoc. researchers:Augusto Ducati Luchessi

Abstract

During the last decades, many attempts have been made to produce functional vascular substitutes that can be used to repair diseased blood vessels. However, currently available substitutes have presented inadequate mechanical, physiological or functional properties, leading to thrombosis or intimal hyperplasia following surgery. In this way, the objective of this study is to produce small-caliber (<6 mm) vascular substitutes using scaffolds to mimic the structure, morphology, mechanical and biological properties of the native blood vessels, having antithrombogenic properties and may hold the potential to repair blood vessels for vascular repair. In this way, scaffolds will be fabricated by rotary jet spinning polymer based on collagen, elastin and polyurethane. The influence of the fibers on the structure and morphology of the scaffolds will be evaluated using scanning electron microscopy and Fourier transform infrared spectroscopy. Thermal properties will be evaluated by thermogravimetry analysis. Mechanical properties will be evaluated using universal testing machine. Biological properties will be evaluated by blood platelet adhesion, cell adhesion, viability, proliferation and cell cycle. The biodegradation of the scaffolds will also be tested using in vitro mass loss. (AU)

Articles published in other media outlets (16 total):
More itemsLess items
Pesquisa da UNICAMP produz novo biomaterial para regeneração de ossos 
Brasileiros criam biomaterial que pode regenerar ossos 
Brasileiros criam biomaterial que pode regenerar ossos 
Brasileiros criam biomaterial que pode regenerar ossos 
Biomaterial que pode regenerar ossos é criado no Brasil 
Brasileiros criam biomaterial que pode regenerar ossos 
Brasileiros criam biomaterial que pode regenerar ossos 
Brasileiros criam biomaterial que pode regenerar ossos 
Unicamp produz biomaterial que regenera ossos 
Pesquisa da Unicamp produz novo biomaterial para regeneração de ossos 
Pesquisa da Unicamp produz novo material que ajuda a regenerar ossos 
Pesquisa da UNICAMP produz novo biomaterial para regenaração de ossos 
Pesquisa da Unicamp produz novo biomaterial para regeneração de ossos 
Pesquisa da Unicamp produz novo biomaterial para regeneração de ossos 
Pesquisa da Unicamp produz novo biomaterial para regeneração de ossos 
Pesquisa da Unicamp produz novo biomaterial para regeneração de ossos 

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEREIRA RODRIGUES, ISABELLA CAROLINE; TAMBORLIN, LETICIA; RODRIGUES, ANA AMELIA; JARDINI, ANDRE LUIZ; LUCHESSI, AUGUSTO DUCATI; MACIEL FILHO, RUBENS; NAJAR LOPES, EDER SOCRATES; GABRIEL, LAIS PELLIZZER. Polyurethane fibrous membranes tailored by rotary jet spinning for tissue engineering applications. Journal of Applied Polymer Science, v. 137, n. 11 MAR 15 2020. Web of Science Citations: 0.
PEREIRA RODRIGUES, ISABELLA CAROLINE; TAMBORLIN, LETICIA; RODRIGUES, ANA AMELIA; JARDINI, ANDRE LUIZ; LUCHESSI, AUGUSTO DUCATI; MACIEL FILHO, RUBENS; NAJAR LOPES, EDER SOCRATES; GABRIEL, LAIS PELLIZZER. Polyurethane fibrous membranes tailored by rotary jet spinning for tissue engineering applications. Journal of Applied Polymer Science, SEP 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.