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Synthetic and natural polymers applied to tissue engineering

Grant number: 11/21442-6
Support type:Research Projects - Thematic Grants
Duration: February 01, 2013 - January 31, 2019
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Luiz Henrique Catalani
Grantee:Luiz Henrique Catalani
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Ana Campa ; Maria Rita dos Santos e Passos Bueno ; Rafael Luis Boemo ; Silvya Stuchi Maria-Engler
Associated grant(s):14/50154-7 - Evaluation of electrospun scaffolds as biomaterials for bone regeneration, AP.R
Associated scholarship(s):18/11429-1 - Study of adsorption and desorption of lysine on self-assembled layer by layer films by means of FRET, BP.IC
17/24873-4 - PHBV and hydroxybutyrate functionalized CNT nanocomposite: kinetic study of crystallization and correlation with mechanical properties, BP.PD
18/03905-8 - Development of techniques of gel permeation chromatography (GPC), BP.TT
+ associated scholarships 16/08992-0 - Synthesis and crosslinking of unsaturated polyesters derived from isosorbide for use in high resolution 3D printers, BP.IC
15/19694-8 - Bioactivity of multi-layer membranes loaded with various protein markers for tissue engineering applications, BP.PD
15/10009-0 - Protein reservoirs from multi layers assembled onto PLLA and PCL films, BP.IC
14/00155-7 - Development of polymeric biomaterials containing pharmacological activity, BP.IC
13/19748-5 - Effect of magnetic fields on cell proliferation and its application as a device for tissue engineering, BP.PD - associated scholarships


The Polymeric Biomaterials Laboratory, responsible for implementing this project, has developed in recent years, various polymeric materials for applications in biomedical engineering. This project has as the overall goal the development of scaffolds for cell growth from novel, biodegradable and bioabsorbable polymeric systems. It is intended to create conditions for the control of fundamental properties of the scaffolds for optimization of the artificial tissues creation. Thus, we propose the synthesis and study of a new class of biodegradable polymers for use in biomedicine from a family of polyesters and polyanhydrides derived from dehydroalditols. As basic processing technique, we will use electrospinning, a technique that generates porous meshes exceptionally suitable for production of thin scaffolds. The processes of cell adhesion and proliferation will be tested from culture of basic cellular types. As target tissues, we propose the production of grafts models in the reconstitution of bone defects and treatment of periodontitis, grafts for the regeneration of perforated tympanic membranes, as well as the construction of neural tissue from mesenchymal stem cells. We also propose to study the association of inorganic and/or proteic additives in order to conduct the processes of interest such as the amplification of cell adhesion and proliferation, differentiation, recruitment, stimulation of homeostasis, extracellular matrix production, and any other process for tissue regeneration. (AU)

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Scientific publications (14)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
IMMICH, A. P. S.; PENNACCHI, P. C.; NAVES, A. F.; FELISBINO, S. L.; BOEMO, R. L.; MARIA-ENGLER, S. S.; CATALANI, L. H.. Improved tympanic membrane regeneration after myringoplastic surgery using an artificial biograft. Materials Science & Engineering C-Materials for Biological Applications, v. 73, p. 48-58, . (11/21442-6, 11/22812-1, 11/18017-1)
NAVES, ALLINY F.; FERNANDES, HENRIQUE T. C.; IMMICH, ANA P. S.; CATALANI, LUIZ H.. Enzymatic syntheses of unsaturated polyesters based on isosorbide and isomannide. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, v. 51, n. 18, p. 3881-3891, . (11/21442-6, 08/06445-6, 05/02855-7, 11/18017-1)
SRINIVASAN, BASKAR; KOLANTHAI, ELAYARAJA; KUMARASWAMY, NIVETHAA ELUPPAI ASTHAGIRI; PUGAZHENDHI, ABINAYA SINDU; CATALANI, LUIZ HENRIQUE; SUBBARAYA, NARAYANA KALKURA. Vacancy-Induced Visible Light-Driven Fluorescence in Toxic Ion-Free Resorbable Magnetic Calcium Phosphates for Cell Imaging Applications. ACS APPLIED BIO MATERIALS, v. 4, n. 4, p. 3256-3263, . (15/19694-8, 11/21442-6)
DELECHIAVE, GIOVANNE; NAVES, ALLINY F.; KOLANTHAI, ELAYARAJA; DA SILVA, RUBENS A.; VLASMAN, RAPHAEL C.; PETRI, DENISE F. S.; TORRESI, ROBERTO M.; CATALANI, LUIZ H.. Tuning protein delivery from different architectures of layer-by-layer assemblies on polymer films. MATERIALS ADVANCES, v. 1, n. 6, p. 2043-2056, . (18/14532-8, 11/21442-6, 17/06394-1, 15/19694-8, 18/13492-2, 15/10009-0)
MALLAUPOMA CAMARENA, DENISSE ESTHER; ALCANTARA SEKIMOTO MATSUYAMA, LARISSA SATIKO; MARIA-ENGLER, SILVYA STUCHI; CATALANI, LUIZ HENRIQUE. Development of Epidermal Equivalent from Electrospun Synthetic Polymers for In Vitro Irritation/Corrosion Testing. NANOMATERIALS, v. 10, n. 12, . (11/21442-6, 18/13492-2, 17/04926-6, 19/14527-7)
BUENO, VANIA BLASQUES; BENTINI, RICARDO; CATALANI, LUIZ HENRIQUE; BARBOSA, LEANDRO R. S.; SIQUEIRA PETRI, DENISE FREITAS. Synthesis and characterization of xanthan-hydroxyapatite nanocomposites for cellular uptake. Materials Science & Engineering C-Materials for Biological Applications, v. 37, p. 195-203, . (11/21442-6, 10/13034-2)
GONCALVES, FLAVIA; BENTINI, RICARDO; BURROWS, MARIANA C.; CARREIRA, ANA C. O.; KOSSUGUE, PATRICIA M.; SOGAYAR, MARI C.; CATALANI, LUIZ H.. Hybrid Membranes of PLLA/Collagen for Bone Tissue Engineering: A Comparative Study of Scaffold Production Techniques for Optimal Mechanical Properties and Osteoinduction Ability. MATERIALS, v. 8, n. 2, p. 408-423, . (11/21442-6, 10/17698-2)
MERINDOL, REMI; DELECHIAVE, GIOVANNE; HEINEN, LAURA; CATALANI, LUIZ HENRIQUE; WALTHER, ANDREAS. Modular Design of Programmable Mechanofluorescent DNA Hydrogels. NATURE COMMUNICATIONS, v. 10, . (11/21442-6, 16/22778-1)
KOLANTHAI, ELAYARAJA; SINDU, PUGAZHENDHI ABINAYA; KHAJURIA, DEEPAK KUMAR; VEERLA, SARATH CHANDRA; KUPPUSWARNY, DHANDAPANI; CATALANI, LUIZ HENRIQUE; MAHAPATRA, D. ROY. Graphene Oxide-A Tool for the Preparation of Chemically Crosslinking Free Alginate-Chitosan-Collagen Scaffolds for Bone Tissue Engineering. ACS APPLIED MATERIALS & INTERFACES, v. 10, n. 15, p. 12441-12452, . (11/21442-6, 15/19694-8)
DO AMARAL MONTANHEIRO, THAIS LARISSA; MONTAGNA, LARISSA STIEVEN; PATRULEA, VIORICA; JORDAN, OLIVIER; BORCHARD, GERRIT; MONTEIRO LOBATO, GABRIELA MATHEUS; CATALANI, LUIZ HENRIQUE; LEMES, ANA PAULA. Evaluation of cellulose nanocrystal addition on morphology, compression modulus and cytotoxicity of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) scaffolds. Journal of Materials Science, v. 54, n. 9, p. 7198-7210, . (11/21442-6, 13/27064-9)
DE SOUZA, DIEGO CLEMENTE; VAHIA DE ABREU, HENRIQUE DE LUCA; DE OLIVEIR, PEDRO VITORIANO; CAPELO, LUCIANE PORTAS; PASSOS-BUENO, MARIA RITA; CATALANI, LUIZ HENRIQUE. A fast degrading PLLA composite with a high content of functionalized octacalcium phosphate mineral phase induces stem cells differentiation. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v. 93, p. 93-104, . (11/21442-6, 17/22599-2, 13/08028-1)
SRINIVASAN, BASKAR; KOLANTHAI, ELAYARAP; KUMARASWAMY, NIVETHAA ELUPPAI ASTHAGIRI; JAYAPALAN, RAMANA RAMYA; VAVILAPALLI, DURGA SANKAR; CATALANI, LUIZ HENRIQUE; NINGOMBAM, GOUTAM SINGH; KHUNDRAKPAM, NEHRU SINGH; SINGH, NONGMAITHEM RAJMUHON; KALKURA, SUBBARAYA NARAYANA. Thermally Modified Iron-Inserted Calcium Phosphate for Magnetic Hyperthermia in an Acceptable Alternating Magnetic Field. Journal of Physical Chemistry B, v. 123, n. 26, p. 5506-5513, . (15/19694-8, 11/21442-6)
ALVES, EDUARDO; MALUF, FERNANDO V.; BUENO, VANIA B.; GUIDO, RAFAEL V. C.; OLIVA, GLAUCIUS; SINGH, MANEESH; SCARPELLI, PEDRO; COSTA, FAHYME; SARTORELLO, ROBSON; CATALANI, LUIZ H.; et al. Biliverdin targets enolase and eukaryotic initiation factor 2 (eIF2 alpha) to reduce the growth of intraerythrocytic development of the malaria parasite Plasmodium falciparum. SCIENTIFIC REPORTS, v. 6, . (11/21442-6, 13/07600-3, 11/51295-5)
GONCALVES, FLAVIA; DE MORAES, MIRIAM SANTOS; FERREIRA, LORRAINE BRAGA; OLIVEIRA CARREIRA, ANA CLAUDIA; KOSSUGUE, PATRICIA MAYUMI; CIDREIRA BOARO, LETICIA CRISTINA; BENTINI, RICARDO; DA SILVA GARCIA, CELIA REGINA; SOGAYAR, MARI CLEIDE; ARANA-CHAVEZ, VICTOR ELIAS; et al. Combination of Bioactive Polymeric Membranes and Stem Cells for Periodontal Regeneration: In Vitro and In Vivo Analyses. PLoS One, v. 11, n. 3, . (11/21442-6, 10/17698-2, 11/51295-5)

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Filed patent(s) as a result of this research project

Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação BR1020170254585 - Universidade de São Paulo (USP) . Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - November 2017, 27