Advanced search
Start date
Betweenand

Synthetic and natural scaffolds applied to regenerative medicine

Grant number: 18/13492-2
Support type:Research Projects - Thematic Grants
Duration: February 01, 2019 - January 31, 2024
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Luiz Henrique Catalani
Grantee:Luiz Henrique Catalani
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Principal researchers:Denise Freitas Siqueira Petri ; Susana Inés Córdoba de Torresi
Assoc. researchers:Alexander Henning Ulrich ; Alexandre Bruni Cardoso ; Daniel Reinaldo Cornejo ; Flavia Vischi Winck ; José Eduardo Krieger ; Mari Cleide Sogayar ; Mauricio da Silva Baptista ; Roberto Manuel Torresi ; Silvya Stuchi Maria-Engler
Associated grant(s):19/22671-0 - Peptides-polysaccharides conjugates as antimicrobial materials for 3D printing, AP.R SPRINT
19/15781-4 - Study of adhesion and proliferation of stem cells in capacitive electrical stimuli over scaffolds in 2D and 3D made by electrospinning and Solution Blow Spinning, AP.R SPRINT
19/08178-0 - Multi-User Equipment approved in grant 2018/13492-2: atomic force microscope, AP.EMU
Associated scholarship(s):20/15005-1 - A solvent-free route for the synthesis of the composite AuNPs@PEDOT-co-PDLLA e its biomedical applications, BP.IC
20/03248-7 - Study on the release of caffeine from magnetic xanthan scaffolds under magnetic stimulus, BP.IC
20/05632-9 - Nanotopography and nanomechanical properties of nanostructured chitosan scaffolds and of cells adhered on them, BP.DR
+ associated scholarships 20/01907-3 - Determination of mechanical properties of polysaccharide-based magnetic scaffolds, BP.PD
19/20405-1 - Techniques development on gel permeation chromatography (GPC), BP.TT
19/19980-1 - Development of catalytic scaffolds, BP.IC
19/10789-7 - Novel cellular scaffold from a histidine rich recombinant elastin-derived protein for 3D printing, BP.PD
19/12466-0 - Biodegradavel and biocompativel materials based on conducting polymers, BP.IC
19/12962-8 - Synthesis of polyesters based on panthenol via chemical catalysis, BP.IC
19/05732-6 - Synthetic and natural scaffolds applied to regenerative medicine, BP.TT
19/06677-9 - Study of lysozyme adsorption and desorption in layer-by-layer films by means of FRET, BP.IC
19/02669-1 - Quartz crystal microbalance with dissipation for characterization of adsorption/adhesion processes of proteins and cells on biomaterials, BP.TT - associated scholarships

Abstract

This project has as its general goal the development of scaffolds for cellular growth from novel polymer systems, aiming at applications in biomedical engineering, especially in the area of regenerative medicine. We propose the combination of the efforts of specialists from various areas toward a multi- and interdisciplinary approach, in the solution of problems involving the control of several fundamental properties of the materials here used in the generation of artificial tissues. Hence, this project proposes the generation of scaffolds that exhibits chemical, physical and biological stimuli, aimed at the control of cellular responses, such as adhesion, proliferation, and differentiation. Among the chemical stimuli, we propose the functionalization of the surfaces with layer-by-layer systems, to include protein signaling molecules, as well as the use of decellularized and fractions of a digested extracellular matrix in the production of hybrid scaffolds. As physical stimuli, we propose the study of scaffolds produced with conducting polymers and magnetic nanoparticles, to examine how they can control the various biological events, and what mechanisms are involved. Also, we intend to add to the associated laboratories with last generation processing techniques, such as electrospinning and 3D printing, allowing picturing the role of morphology in biological events. To make the best use of these processing techniques, we propose the study of novel materials, with thermoset and photo-curing properties. In this way, it is necessary to provide adequate microscopic techniques capable of producing mechanical and conductive analyzes of the surfaces thus generated. The essence of the project is the integration of distinct but complementary approaches to understanding the complex relationship between material, architecture and cellular response. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
Reutilizar, reemplazar, degradar 
Reuse, replace, degrade 
Articles published in other media outlets (7 total):
More itemsLess items
APWR - Associação Park Way Residencial: Estamos respirando e ingerindo microplástico. Onde isso vai parar? (29/Jul/2019)
Espaço Ecológico no Ar: As melhores opções para acabar com o plástico no planeta, segundo especialistas (25/Jul/2019)
Acaps - Associação Capixaba de Supermercados: As melhores opções para acabar com o plástico no planeta, segundo especialistas (24/Jul/2019)
Espaço Ecológico no Ar: Estamos respirando e ingerindo microplástico. Onde isso vai parar? (23/Jul/2019)
greenMe!: As melhores opções para acabar com o plástico no planeta, segundo especialistas (23/Jul/2019)
greenMe!: Estamos respirando e ingerindo microplástico. Onde isso vai parar? (22/Jul/2019)
Sou Resíduo Zero: Reutilizar, substituir, degradar (15/Jul/2019)

Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TUNDISI, L. L.; MOSTACO, G. B.; CARRICONDO, P. C.; PETRI, D. F. S. Hydroxypropyl methylcellulose: Physicochemical properties and ocular drug delivery formulations. European Journal of Pharmaceutical Sciences, v. 159, APR 1 2021. Web of Science Citations: 0.
RIBEIRO DE BARROS, HELOISE; GARCIA, ISABEL; KUTTNER, CHRISTIAN; ZEBALLOS, NICOLL; CAMARGO, PEDRO H. C.; CORDOBA DE TORRESI, SUSANA INES; LOPEZ-GALLEGO, FERNANDO; LIZ-MARZAN, LUIS M. Mechanistic Insights into the Light-Driven Catalysis of an Immobilized Lipase on Plasmonic Nanomaterials. ACS CATALYSIS, v. 11, n. 1, p. 414-423, JAN 1 2021. Web of Science Citations: 0.
MALLAUPOMA CAMARENA, DENISSE ESTHER; ALCANTARA SEKIMOTO MATSUYAMA, LARISSA SATIKO; MARIA-ENGLER, SILVYA STUCHI; CATALANI, LUIZ HENRIQUE. Development of Epidermal Equivalent from Electrospun Synthetic Polymers for In Vitro Irritation/Corrosion Testing. NANOMATERIALS, v. 10, n. 12 DEC 2020. Web of Science Citations: 0.
DELECHIAVE, GIOVANNE; NAVES, ALLINY F.; KOLANTHAI, ELAYARAJA; DA SILVA, RUBENS A.; VLASMAN, RAPHAEL C.; PETRI, DENISE F. S.; TORRESI, ROBERTO M.; CATALANI, LUIZ H. Tuning protein delivery from different architectures of layer-by-layer assemblies on polymer films. MATERIALS ADVANCES, v. 1, n. 6, p. 2043-2056, SEP 1 2020. Web of Science Citations: 0.
DA SILVA, ARUA C.; DA SILVA, RUBENS A.; SOUZA, MARIA J. P. G.; MONTOYA, PAULA M.; BENTINI, RICARDO; AUGUSTO, TATIANA; TORRESI, ROBERTO M.; CATALANI, LUIZ H.; DE TORRESI, SUSANA I. CORDOBA. Electrochemical quartz crystal microbalance with dissipation investigation of fibronectin adsorption dynamics driven by electrical stimulation onto a conducting and partially biodegradable copolymer. BIOINTERPHASES, v. 15, n. 2 MAR 2020. Web of Science Citations: 0.
LEITE, MARINA M.; MARTINS, VITOR L.; VICHI, FLAVIO M.; TORRESI, ROBERTO M. Electrochemistry of sodium titanate nanotubes as a negative electrode for sodium-ion batteries. Electrochimica Acta, v. 331, JAN 20 2020. Web of Science Citations: 3.
FRACHINI, EMILLI C. G.; PETRI, DENISE F. S. Magneto-Responsive Hydrogels: Preparation, Characterization, Biotechnological and Environmental Applications. Journal of the Brazilian Chemical Society, v. 30, n. 10, SI, p. 2010-2028, OCT 2019. Web of Science Citations: 0.
DA SILVA SUSANA, ARUA C.; CORDOBA DE TORRESI, I. Advances in Conducting, Biodegradable and Biocompatible Copolymers for Biomedical Applications. FRONTIERS IN MATERIALS, v. 6, MAY 8 2019. Web of Science Citations: 3.
EMILLI C. G. FRACHINI; DENISE F. S. PETRI. Magneto-Responsive Hydrogels: Preparation, Characterization, Biotechnological and Environmental Applications. Journal of the Brazilian Chemical Society, v. 30, n. 10, p. 2010-2028, Out. 2019.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.