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Synthetic and natural scaffolds applied to regenerative medicine

Grant number: 18/13492-2
Support type:Research Projects - Thematic Grants
Duration: February 01, 2019 - January 31, 2024
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Luiz Henrique Catalani
Grantee:Luiz Henrique Catalani
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Pesquisadores principais:
Denise Freitas Siqueira Petri ; Susana Inés Córdoba de Torresi
Assoc. researchers:Alexander Henning Ulrich ; Alexandre Bruni Cardoso ; Daniel Reinaldo Cornejo ; Flavia Vischi Winck ; José Eduardo Krieger ; Mari Cleide Sogayar ; Mauricio da Silva Baptista ; Roberto Manuel Torresi ; Silvya Stuchi Maria-Engler
Associated grant(s):19/22671-0 - Peptides-polysaccharides conjugates as antimicrobial materials for 3D printing, AP.R SPRINT
19/15781-4 - Study of adhesion and proliferation of stem cells in capacitive electrical stimuli over scaffolds in 2D and 3D made by electrospinning and Solution Blow Spinning, AP.R SPRINT
19/08178-0 - Multi-User Equipment approved in grant 2018/13492-2: atomic force microscope, AP.EMU
Associated scholarship(s):22/01784-4 - Atomic force microscopy for the characterization of scaffolds: topography, adhesion forces, BP.TT
22/01164-6 - Biomaterials based on biodegradable conducting polymers and bioplasmonics, BP.PD
21/14039-2 - Development of gel permeation chromatography (GPC) techniques, BP.TT
+ associated scholarships 21/12024-8 - Atomic force microscopy for the characterization of scaffolds: topography, adhesion forces, elasticity modulus, electric potential, BP.TT
21/00490-4 - Study of functional and photoreticulable hydrogels derived from biopolymers for application in 3D printing, BP.DD
20/15986-2 - Synthesis and characterization of photocrosslinkable and functionalizable polypeptides for 3D print, BP.DD
20/15005-1 - A solvent-free route for the synthesis of the composite AuNPs@PEDOT-co-PDLLA e its biomedical applications, BP.IC
20/03248-7 - Study on the release of caffeine from magnetic xanthan scaffolds under magnetic stimulus, BP.IC
20/05632-9 - Nanotopography and nanomechanical properties of nanostructured chitosan scaffolds and of cells adhered on them, BP.DR
20/01907-3 - Determination of mechanical properties of polysaccharide-based magnetic scaffolds, BP.PD
19/20405-1 - Techniques development on gel permeation chromatography (GPC), BP.TT
19/19980-1 - Development of catalytic scaffolds, BP.IC
19/10789-7 - Novel cellular scaffold from a histidine rich recombinant elastin-derived protein for 3D printing, BP.PD
19/12466-0 - Biodegradavel and biocompativel materials based on conducting polymers, BP.IC
19/12962-8 - Synthesis of polyesters based on panthenol via chemical catalysis, BP.IC
19/05732-6 - Synthetic and natural scaffolds applied to regenerative medicine, BP.TT
19/06677-9 - Study of lysozyme adsorption and desorption in layer-by-layer films by means of FRET, BP.IC
19/02669-1 - Quartz crystal microbalance with dissipation for characterization of adsorption/adhesion processes of proteins and cells on biomaterials, BP.TT - associated scholarships


This project has as its general goal the development of scaffolds for cellular growth from novel polymer systems, aiming at applications in biomedical engineering, especially in the area of regenerative medicine. We propose the combination of the efforts of specialists from various areas toward a multi- and interdisciplinary approach, in the solution of problems involving the control of several fundamental properties of the materials here used in the generation of artificial tissues. Hence, this project proposes the generation of scaffolds that exhibits chemical, physical and biological stimuli, aimed at the control of cellular responses, such as adhesion, proliferation, and differentiation. Among the chemical stimuli, we propose the functionalization of the surfaces with layer-by-layer systems, to include protein signaling molecules, as well as the use of decellularized and fractions of a digested extracellular matrix in the production of hybrid scaffolds. As physical stimuli, we propose the study of scaffolds produced with conducting polymers and magnetic nanoparticles, to examine how they can control the various biological events, and what mechanisms are involved. Also, we intend to add to the associated laboratories with last generation processing techniques, such as electrospinning and 3D printing, allowing picturing the role of morphology in biological events. To make the best use of these processing techniques, we propose the study of novel materials, with thermoset and photo-curing properties. In this way, it is necessary to provide adequate microscopic techniques capable of producing mechanical and conductive analyzes of the surfaces thus generated. The essence of the project is the integration of distinct but complementary approaches to understanding the complex relationship between material, architecture and cellular response. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
Reutilizar, reemplazar, degradar 
Reuse, replace, degrade 
Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (12)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA SUSANA, ARUA C.; CORDOBA DE TORRESI, I.. Advances in Conducting, Biodegradable and Biocompatible Copolymers for Biomedical Applications. FRONTIERS IN MATERIALS, v. 6, . (15/26308-7, 17/00705-5, 14/09353-6, 18/13492-2)
FRACHINI, EMILLI C. G.; PETRI, DENISE F. S.. Magneto-Responsive Hydrogels: Preparation, Characterization, Biotechnological and Environmental Applications. Journal of the Brazilian Chemical Society, v. 30, n. 10, SI, p. 2010-2028, . (18/13492-2)
LEITE, MARINA M.; MARTINS, VITOR L.; VICHI, FLAVIO M.; TORRESI, ROBERTO M.. Electrochemistry of sodium titanate nanotubes as a negative electrode for sodium-ion batteries. Electrochimica Acta, v. 331, . (15/26308-7, 19/02669-1, 18/13492-2)
RIBEIRO DE BARROS, HELOISE; GARCIA, ISABEL; KUTTNER, CHRISTIAN; ZEBALLOS, NICOLL; CAMARGO, PEDRO H. C.; CORDOBA DE TORRESI, SUSANA INES; LOPEZ-GALLEGO, FERNANDO; LIZ-MARZAN, LUIS M.. Mechanistic Insights into the Light-Driven Catalysis of an Immobilized Lipase on Plasmonic Nanomaterials. ACS CATALYSIS, v. 11, n. 1, p. 414-423, . (18/13492-2, 19/09668-0, 15/26308-7, 17/20892-4)
DA SILVA, ARUA C.; DA SILVA, RUBENS A.; SOUZA, MARIA J. P. G.; MONTOYA, PAULA M.; BENTINI, RICARDO; AUGUSTO, TATIANA; TORRESI, ROBERTO M.; CATALANI, LUIZ H.; DE TORRESI, SUSANA I. CORDOBA. Electrochemical quartz crystal microbalance with dissipation investigation of fibronectin adsorption dynamics driven by electrical stimulation onto a conducting and partially biodegradable copolymer. BIOINTERPHASES, v. 15, n. 2, . (18/13492-2, 17/08349-3, 15/26308-7, 17/00705-5, 14/09353-6)
DEZOTTI, RAFAEL S.; FURTADO, LAISE M.; YEE, MARCIO; VALERA, TICIANE S.; BALAJI, KRISHNASAMY; ANDO, ROMULO A.; PETRI, DENISE F. S.. Tuning the Mechanical and Thermal Properties of Hydroxypropyl Methylcellulose Cryogels with the Aid of Surfactants. GELS, v. 7, n. 3, . (18/13492-2)
LIBERATO, MICHELLE S.; CAVALCANTE, NAYARA G. S.; SINDU, P. ABINAYA; RODRIGUES-JESUS, MONICA J.; ZELENOVSKII, PAVEL; CARREIRA, ANA C. O.; BAPTISTA, MAURICIO S.; SOGAYAR, MARI C.; FERREIRA, LUIS C. S.; CATALANI, LUIZ H.. Histidine-based hydrogels via singlet-oxygen photooxidation. SOFT MATTER, v. 17, n. 48, . (18/13492-2, 19/08975-7, 19/10789-7)
TUNDISI, L. L.; MOSTACO, G. B.; CARRICONDO, P. C.; PETRI, D. F. S.. Hydroxypropyl methylcellulose: Physicochemical properties and ocular drug delivery formulations. European Journal of Pharmaceutical Sciences, v. 159, . (18/13492-2)
DELECHIAVE, GIOVANNE; NAVES, ALLINY F.; KOLANTHAI, ELAYARAJA; DA SILVA, RUBENS A.; VLASMAN, RAPHAEL C.; PETRI, DENISE F. S.; TORRESI, ROBERTO M.; CATALANI, LUIZ H.. Tuning protein delivery from different architectures of layer-by-layer assemblies on polymer films. MATERIALS ADVANCES, v. 1, n. 6, p. 2043-2056, . (18/14532-8, 11/21442-6, 17/06394-1, 15/19694-8, 18/13492-2, 15/10009-0)
MALLAUPOMA CAMARENA, DENISSE ESTHER; ALCANTARA SEKIMOTO MATSUYAMA, LARISSA SATIKO; MARIA-ENGLER, SILVYA STUCHI; CATALANI, LUIZ HENRIQUE. Development of Epidermal Equivalent from Electrospun Synthetic Polymers for In Vitro Irritation/Corrosion Testing. NANOMATERIALS, v. 10, n. 12, . (11/21442-6, 18/13492-2, 17/04926-6, 19/14527-7)
BARROS, HELOISE RIBEIRO; TANAKA, LIVIA YUKARI; PACHECO DA SILVA, RAFAEL TRIVELLA; SANTIAGO-ARCOS, JAVIER; CORDOBA TORRESI, I, SUSANA; LOPEZ-GALLEGO, FERNANDO. Assembly of Nano-Biocatalyst for the Tandem Hydrolysis and Reduction of p-Nitrophenol Esters. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, v. 38, n. 10, . (19/19551-3, 18/02435-8, 17/20892-4, 15/26308-7, 18/13492-2, 19/09668-0)
MENESES, IZABO PEREIRA; NOVAES, STEPHANIE DIAS; DEZOTTI, RAFAEL SOBRAL; OLIVEIRA, PEDRO VITORIANO; SIQUEIRA PETRI, DENISE FREITAS. CTAB-modified carboxymethyl cellulose/bagasse cryogels for the efficient removal of bisphenol A, methylene blue and Cr(VI) ions: Batch and column adsorption studies. JOURNAL OF HAZARDOUS MATERIALS, v. 421, . (18/13492-2)

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