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Synthetic polymers applied to biomaterials

Grant number: 05/02855-7
Support type:Research Projects - Thematic Grants
Duration: March 01, 2006 - February 28, 2011
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Luiz Henrique Catalani
Grantee:Luiz Henrique Catalani
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Ana Campa ; Antônio Jedson Caldeira Brant ; Guilhermino José Macêdo Fechine ; Janaina Aline Galvao Barros ; Reginaldo Faichel da Silva ; Romeu Casarano ; Vânia Aparecida Blasques Bueno Silva
Associated scholarship(s):11/01164-1 - Degradation study of polyesters containing dianhydrohexitols obtained by enzymatic synthesis, BP.IC
10/14720-7 - Production of aligned nanofibers from biodegradable polymers for growth and regeneration of neuronal cells, BP.MS
08/07960-1 - Study of biomacromolecules immobilization onto polyester nanofiber, BP.MS
08/06445-6 - New biodegradable polyesters by enzymatic synthesis: use of monomers based on renewable sources, BP.PD

Abstract

Our group has invested in the development of technologies for hydrogel production that are of low cost, of easy access and that can produce nontoxic gels, intended to the production of dressings and other applications as biomaterials. As consequence of these studies, two patents recently have been deposited. We have devoted, also, to other synthetic polymer areas with prospect on its application as biomaterials. Moreover, the main researcher of this project (LHC) acquired specialized knowledge in the technique of polymer electrospinning and production of polyesters derived from dehydroalditols, during a sabbatical period (from 06/2004 to 07/2005) in the Medical Device Concept Laboratory of New Jersey Institute of Technology. The developed technologies of hydrogel production of PVP allow us to envisage new applications of these materials. Since it allows the almost instantaneous formation of the gel, we are considering its application as dressings where you can freely shape or mold, without a pre-established form, and that they can act as drug release devices, with antibacterial and antifungal functions. This opens the prospect for exploration of other intelligent dressings, combined with enzymatic action. In this in case, the production of gels of high porosity is necessary and we consider the use of electrospinning for generation of membranes in non-woven form (mat). The crosslinking after spinning of these mats should generate a firm hydrogel of high porosity, capable of being loaded with enzymatic activity. Alternatively, other types of drugs of high molecular weight could be integrated to these membranes. We intend to use these technologies in the production of micro and nanostructure materials. Nano particles can be obtained using several types of matrices. In this project, we will use vesicles and reverse micelles as formatting systems. The crosslinking of the immobilized gel within the water compartment will be carried out through Fenton reaction. Likewise, we will develop hydrogels of micrometric and sub-micrometric structure by imprinting in inert matrices through the crosslinking of PVP films using UV photolithography technique, defining the contour conditions and resolution limits of impression. In the area of polyesters, we are interest in two fields related to the development of implants: 1) biodegradable or bioerodable polyesters and 2) modification of (the surface of) polyesters of high performance (PET, PTT and PBT). In the first case, the focus is the modification of the poly (Iactic acid) system by copolymerization with dehydroalditols e diacids, biomass derived monomers. Initial tests in our group indicate that these materials show physical and chemical properties that point out to high biodegradation kinetics. This kind of property has great appeal in applications where the projection of the implant lifetime the must be critically controlled. In addition, our interests in high performance polyesters have been in its use as scaffold for cellular growth and grafts. Here, the surface properties of the material must be controlled in order to guarantee biocompatibility and durability. Since the materials here proposed are in its majority unknown and shall integrate biomedical devices, its interaction with active blood cells is essential tests to evaluate its viability as biomaterials. Counting on expertise of the Group of Macrophages Activation (AC - co-signatory), we plan to study the resulting events of the interaction of materials here produced with blood cells, such as monocytes and neutrophils, especially those related to cellular adhesion, differentiation and signaling. (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Scientists develop a polymer made from corn 

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NAVES, ALLINY F.; FERNANDES, HENRIQUE T. C.; IMMICH, ANA P. S.; CATALANI, LUIZ H. Enzymatic syntheses of unsaturated polyesters based on isosorbide and isomannide. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, v. 51, n. 18, p. 3881-3891, SEP 15 2013. Web of Science Citations: 23.
JUAIS, DANIELLE; NAVES, ALLINY F.; LI, CHONG; GROSS, RICHARD A.; CATALANI, LUIZ H. Isosorbide Polyesters from Enzymatic Catalysis. MACROMOLECULES, v. 43, n. 24, p. 10315-10319, DEC 28 2010. Web of Science Citations: 57.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
Filed patent(s) as a result of this research project

MEMBRANA DE HIDROGEL E CURATIVO INTELIGENTE PI0902080-2 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Universidade de São Paulo (USP) . Henrique Eisi Toma; Koiti Araki; Luíz Henrique Catalani; Renata Fogaça da Silva; Vitor de Moraes Zamarion - February 2009, 16

PROCESSO DE OBTENÇÃO DE POLIÉSTERES POR CATÁLISE ENZIMÁTICA, POLIÉSTERES BIODEGRADÁVEIS E SEUS USOS PI1001309-1 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Universidade de São Paulo (USP) . Luiz Henrique Catalani; Danielle Juais; Alliny Ferreira Naves; Richard A. Gross - April 2010, 15