Synthesis and crosslinking of unsaturated polyesters derived from isosorbide for use in high resolution 3D printers

• Grant number: 16/08992-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2016
• End date: June 30, 2017
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Luiz Henrique Catalani
• Grantee: Isabela Lima Autran Dourado
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 11/21442-6 - Synthetic and natural polymers applied to tissue engineering, AP.TEM

Abstract

The objective of this project is to demonstrate the feasibility of using unsaturated polyesters derived from isosorbide (IS) as novel materials for use in absorbable medical devices manufactured by high-resolution 3D printing. From previous group development, it is intended to use copolymers derived from isosorbide adipate (ADIS) containing varying amounts of aliphatic diesters - synthesized from unsaturated aliphatic diacid - such as diethyl fumarate (FU), diethyl glutaconate (GL) and diethyl hydromuconate (HM), thereby creating polymers with thermal and photochemical crosslinking capability. The collaboration with the group of Prof. David Dean, of Ohio State University, shall render the combination of the potential use of these materials with the 3D printing technique for high resolution. It should be noted that this technique differs substantially from conventional 3D printing based on extrusion and sintering. Thus, the project's specific objectives are the up-scale synthesis, generating sufficient amounts of low molecular isosorbide polyester, highly cross-linkable (30 g per batch) for initial testing. The basic and necessary properties of such materials are demonstrated in the project are: low viscosity, whether in native or solvent mixed with a biocompatible material and thermoplastic capacity and photocrosslinking of the polyester obtained. (AU)