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EMG breakthrough during cortical silent period in congenital hemiparesis: a descriptive case series

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Autor(es):
Lixandrao, Maira C. [1, 2] ; Stinear, James W. [3] ; Rich, Tonya [2] ; Chen, Chao-Ying [2] ; Feyma, Tim [4] ; Meekins, Gregg D. [5] ; Gillick, Bernadette T. [2]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed Sao Carlos UFSCar, Dept Phys Therapy, Sao Carlos, SP - Brazil
[2] Univ Minnesota, Sch Med, Div Rehabil Sci, Minneapolis, MN 55455 - USA
[3] Univ Auckland, Ctr Brain Res, Dept Exercise Sci, New Zealand Movement Neurosci Lab, Auckland - New Zealand
[4] Gillette Childrens Specialty Healthcare, St Paul, MN - USA
[5] Univ Minnesota, Sch Med, Dept Neurol, Minneapolis, MN 55455 - USA
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: BRAZILIAN JOURNAL OF PHYSICAL THERAPY; v. 24, n. 1, p. 20-29, JAN-FEB 2020.
Citações Web of Science: 0
Resumo

Background: The cortical silent period is a transient suppression of electromyographic activity after a transcranial magnetic stimulation pulse, attributed to spinal and supraspinal inhibitory mechanisms. Electromyographic breakthrough activity has been observed in healthy adults as a result of a spinal reflex response within the cortical silent period. Objectives: The objective of this case series is to report the ipsilesional and contralesional cortical silent period and the electromyographic breakthrough activity of 7 children with congenital hemiparesis. Methods: TMS was delivered over the ipsilesional and contralesional primary motor cortices with resting motor threshold and cortical silent period measures recorded from first dorsal interosseous muscle. Results: Seven children (13 +/- 2 years) were included. Ipsilesional and contralesional resting motor thresholds ranged from 49 to 80% and from 38 to 63% of maximum stimulator output, respectively. Ipsilesional (n=4) and contralesional (n=7) cortical silent period duration ranged from 49 to 206 ms and 81 to 150 ms, respectively. Electromyographic breakthrough activity was observed ipsilesionally in 3/4 (75%) and contralesionally in 3/7 (42.8%) participants. In the 3 children with ipsilesional breakthrough activity during the cortical silent period, all testing trials showed breakthrough. Contralesional breakthrough activity was observed in only one of the analyzable trials in each of those 3 participants. The mean peak amplitude of breakthrough activity ranged from 45 to 214 mu V (ipsilesional) and from 23 to 93 mu V (contralesional). Conclusion: Further research is warranted to understand the mechanisms and significance of electromyographic breakthrough activity within the cortical silent period in congenital hemiparesis. Understanding these mechanisms may lead to the design of tailored neuromodulation interventions for physical rehabilitation. (C) 2018 Associacao Brasileira de Pesquisa e Pos-Graduacao em Fisioterapia. Published by Elsevier Editora Ltda. All rights reserved. (AU)

Processo FAPESP: 15/16744-4 - Comparação da eficácia da estimulação transcraniana anodal por corrente contínua em duas localizações: eletroencefalograma e hotspot derivado da estimulação magnética transcraniana
Beneficiário:Maíra Carolina Lixandrão
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto