Lanthanum(III) and neodymium(III) complexes with anti-inflammatory drug sulindac: Synthesis, characterization, thermal investigation using coupled techniques TG-FTIR, and in vitro biological studies

Autor(es)

Guerra, Renan B. ^[1] ; de Campos Fraga-Silva, Thais Fernanda ^[2] ; Aguiar, Julia ^[2] ; Oshiro, Paula B. ^[1] ; Holanda, Bruno B. C. ^[1] ; Venturini, James ^{[1, 3]} ; Bannach, Gilbert ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sch Sci, Chem Dept, BR-17033260 Bauru, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Sch Sci, Biol Sci Dept, Bauru, SP - Brazil

^[3] Univ Fed Mato Grosso do Sul, Sch Med, Campo Grande, MS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Inorganica Chimica Acta; v. 503, APR 1 2020.
• Citações Web of Science: 0

Resumo

New lanthanum(III) and neodymium(III) complexes with the anti-inflammatory drug sulindac (Sul) were synthesized and characterized, and their biological activity was evaluated in vitro. The general formula {[}Ln(Sul)(3)]center dot nH(2)O for these complexes was proposed based on thermogravimetry, differential scanning calorimetry, elemental analysis, and complexometric titration using EDTA results. H-1 and C-13 NMR combined with FTIR data results suggested that the carboxylate groups of all three sulindac molecules are coordinated to the metal ions in a bidentate chelate fashion, with no water molecules (OH2) nor sulfinyl groups (S=O) coordinated to the metal center. During thermal decomposition of these complexes, the formation of lanthanide oxyfluorides LaOF and NdO1-xF1+2, was observed and confirmed by powder X-ray diffraction. TG-FTIR coupled techniques were employed to evaluate volatiles released during thermal decomposition of these complexes and compared with the decomposition pattern of the free sulindac, interestingly providing valuable information about the thermosynthesis of the oxyfluorides as well as the coordination modes of sulindac in the complex. Additionally, cell viability and anti-inflammatory assays were performed with human cells to evaluate the in vitro effect of {[}Ln(Sul)(3)]center dot nH(2)O. (AU)

• Processo FAPESP: 97/10949-3 - Aquisição de um difratômetro de raios-x e equipamento de análises térmicas visando dotar os grupos de pesquisa em materiais da Faculdade Ciências Bauru/UNESP
• Beneficiário: Dayse Iara dos Santos
• Modalidade de apoio: Auxílio à Pesquisa - Programa Infraestrutura - Equipamentos
• Processo FAPESP: 17/08820-8 - Síntese e caracterização de biopolímeros a partir de óleos vegetais e glicerol seguindo os princípios da química verde.
• Beneficiário: Gilbert Bannach
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/04096-2 - Síntese, caracterização e avaliação da atividade biológica de metalofármacos de sulindaco com íons lantanídeos (III) no estado sólido
• Beneficiário: Renan Barrach Guerra
• Modalidade de apoio: Bolsas no Brasil - Mestrado