Developmental plasticity allows outside-in immune responses by resident memory T cells

Autor(es):Mostrar menos -

Fonseca, Raissa ^{[1, 2, 3]} ; Beura, Lalit K. ^{[1, 4]} ; Quarnstrom, Clare F. ^[1] ; Ghoneim, Hazem E. ^{[5, 6]} ; Fan, Yiping ^[7] ; Zebley, Caitlin C. ^[6] ; Scott, Milcah C. ^[1] ; Fares-Frederickson, Nancy J. ^[1] ; Wijeyesinghe, Sathi ^[1] ; Thompson, Emily A. ^[1] ; Borges da Silva, Henrique ^[8] ; Vezys, Vaiva ^[1] ; Youngblood, Benjamin ^[6] ; Masopust, David ^[1]

Afiliação do(s) autor(es)

^[1] Univ Minnesota, Sch Med, Dept Microbiol & Immunol, Ctr Immunol, Minneapolis, MN 55455 - USA

^[2] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic - Australia

^[3] Peter Doherty Inst Infect & Immun, Melbourne, Vic - Australia

^[4] Brown Univ, Dept Mol Microbiol & Immunol, Providence, RI 02912 - USA

^[5] Ohio State Univ, Coll Med, Dept Microbial Infect & Immun, Columbus, OH 43210 - USA

^[6] St Jude Childrens Res Hosp, Dept Immunol, 332 N Lauderdale St, Memphis, TN 38105 - USA

^[7] St Jude Childrens Res Hosp, Dept Computat Biol, 332 N Lauderdale St, Memphis, TN 38105 - USA

^[8] Univ Minnesota, Sch Med, Ctr Immunol, Dept Lab Med & Pathol, Minneapolis, MN 55455 - USA

• Tipo de documento: Artigo Científico
• Fonte: NATURE IMMUNOLOGY; v. 21, n. 4 FEB 2020.
• Citações Web of Science: 2

Resumo

Central memory T (T-CM) cells patrol lymph nodes and perform conventional memory responses on restimulation: proliferation, migration and differentiation into diverse T cell subsets while also self-renewing. Resident memory T (T-RM) cells are parked within single organs, share properties with terminal effectors and contribute to rapid host protection. We observed that reactivated T-RM cells rejoined the circulating pool. Epigenetic analyses revealed that T-RM cells align closely with conventional memory T cell populations, bearing little resemblance to recently activated effectors. Fully differentiated T-RM cells isolated from small intestine epithelium exhibited the potential to differentiate into T-CM cells, effector memory T cells and T-RM cells on recall. Ex-T-RM cells, former intestinal T-RM cells that rejoined the circulating pool, heritably maintained a predilection for homing back to their tissue of origin on subsequent reactivation and a heightened capacity to redifferentiate into T-RM cells. Thus, T-RM cells can rejoin the circulation but are advantaged to re-form local T-RM when called on. Tissue-resident memory (T-RM) cells are generally stably maintained in discrete tissues or organs. Masopust and colleagues show that T-RM cells can reenter the circulation, and exhibit considerable plasticity, although they retain a proclivity to reestablish themselves in their tissue of origin. (AU)

• Processo FAPESP: 15/00680-7 - Análise do papel da interação PD-1/PD-L1 no desenvolvimento e função das células T de memória residentes (TRM)
• Beneficiário: Raíssa Fonseca
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto