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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Developmental plasticity allows outside-in immune responses by resident memory T cells

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Autor(es):
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Fonseca, Raissa [1, 2, 3] ; Beura, Lalit K. [1, 4] ; Quarnstrom, Clare F. [1] ; Ghoneim, Hazem E. [5, 6] ; Fan, Yiping [7] ; Zebley, Caitlin C. [6] ; Scott, Milcah C. [1] ; Fares-Frederickson, Nancy J. [1] ; Wijeyesinghe, Sathi [1] ; Thompson, Emily A. [1] ; Borges da Silva, Henrique [8] ; Vezys, Vaiva [1] ; Youngblood, Benjamin [6] ; Masopust, David [1]
Número total de Autores: 14
Afiliação do(s) autor(es):
[1] Univ Minnesota, Sch Med, Dept Microbiol & Immunol, Ctr Immunol, Minneapolis, MN 55455 - USA
[2] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic - Australia
[3] Peter Doherty Inst Infect & Immun, Melbourne, Vic - Australia
[4] Brown Univ, Dept Mol Microbiol & Immunol, Providence, RI 02912 - USA
[5] Ohio State Univ, Coll Med, Dept Microbial Infect & Immun, Columbus, OH 43210 - USA
[6] St Jude Childrens Res Hosp, Dept Immunol, 332 N Lauderdale St, Memphis, TN 38105 - USA
[7] St Jude Childrens Res Hosp, Dept Computat Biol, 332 N Lauderdale St, Memphis, TN 38105 - USA
[8] Univ Minnesota, Sch Med, Ctr Immunol, Dept Lab Med & Pathol, Minneapolis, MN 55455 - USA
Número total de Afiliações: 8
Tipo de documento: Artigo Científico
Fonte: NATURE IMMUNOLOGY; v. 21, n. 4 FEB 2020.
Citações Web of Science: 2
Resumo

Central memory T (T-CM) cells patrol lymph nodes and perform conventional memory responses on restimulation: proliferation, migration and differentiation into diverse T cell subsets while also self-renewing. Resident memory T (T-RM) cells are parked within single organs, share properties with terminal effectors and contribute to rapid host protection. We observed that reactivated T-RM cells rejoined the circulating pool. Epigenetic analyses revealed that T-RM cells align closely with conventional memory T cell populations, bearing little resemblance to recently activated effectors. Fully differentiated T-RM cells isolated from small intestine epithelium exhibited the potential to differentiate into T-CM cells, effector memory T cells and T-RM cells on recall. Ex-T-RM cells, former intestinal T-RM cells that rejoined the circulating pool, heritably maintained a predilection for homing back to their tissue of origin on subsequent reactivation and a heightened capacity to redifferentiate into T-RM cells. Thus, T-RM cells can rejoin the circulation but are advantaged to re-form local T-RM when called on. Tissue-resident memory (T-RM) cells are generally stably maintained in discrete tissues or organs. Masopust and colleagues show that T-RM cells can reenter the circulation, and exhibit considerable plasticity, although they retain a proclivity to reestablish themselves in their tissue of origin. (AU)

Processo FAPESP: 15/00680-7 - Análise do papel da interação PD-1/PD-L1 no desenvolvimento e função das células T de memória residentes (TRM)
Beneficiário:Raíssa Fonseca
Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto