Carboxymethyl-botryosphaeran stabilized carbon nanotubes aqueous dispersion: A new platform design for electrochemical sensing of desloratadine

Autor(es)

Salamanca-Neto, Carlos A. R. ^[1] ; Olean-Oliveira, Andre ^[2] ; Scremin, Jessica ^[1] ; Ceravolo, Graziela S. ^[3] ; Dekker, Robert F. H. ^[4] ; Barbosa-Dekker, Aneli M. ^[5] ; Teixeira, Marcos F. S. ^[2] ; Sartori, Elen R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Londrina, Ctr Ciencias Exatas, Dept Quim, Lab Eletroanalit & Sensores, BR-86057970 Londrina, PR - Brazil

^[2] Univ Estadual Paulista UNESP, Fac Ciencias & Tecnol, Dept Quim & Bioquim, Presidents Prudente, SP - Brazil

^[3] Univ Estadual Londrina, Ctr Ciencias Biol, Dept Fisiol, BR-86057970 Londrina, PR - Brazil

^[4] Univ Tecnol Fed Parana, Programa Posgrad Engn Ambiental, Campus Londrina, BR-86036370 Londrina, PR - Brazil

^[5] Univ Estadual Londrina, Ctr Ciencias Exatas, Dept Quim, BR-86057970 Londrina, PR - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Talanta; v. 210, APR 1 2020.
• Citações Web of Science: 1

Resumo

The polysaccharide carboxymethyl-botryosphaeran (CMB) was used to improve the dispersion of multi-walled carbon nanotubes (MWCNTs) in water. This feature was applied in modifying a glassy carbon electrode (GCE) to construct a sensitive voltammetric sensor for the determination of desloratadine (DESL), a tricyclic antihistamine. The morphology and spectroscopic behavior of the sensor were evaluated. The modified sensor was characterized as homogeneous, and presented a higher electroactive area and a lower charge transfer resistance compared to the unmodified GCE. Using linear sweep voltammetry at 25 mV s(-1), the developed sensor presented a sensitivity of 1.018 mu A L mu mol(-1) in the linear working range of 1.99-32.9 mu mol L-1, with a detection limit of 0.88 mu mol L-1 of DESL in 0.10 mol L-1 potassium hydrogen-phosphate solution (pH 8.0). In addition, the sensor showed excellent repeatability with a relative standard deviation of only 1.02% for a sequence of 10 measurements. The sensor was successfully applied in the analysis of pharmaceutical preparations containing DESL, with equivalent results compared to a validated spectrophotometric method at the 95% confidence level. The sensor was also employed in the analysis of a spiked sample of DESL in rat serum. (AU)

• Processo FAPESP: 13/07296-2 - CDMF - Centro de Desenvolvimento de Materiais Funcionais
• Beneficiário: Elson Longo da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs