| Full text | |
| Author(s): |
Salamanca-Neto, Carlos A. R.
[1]
;
Olean-Oliveira, Andre
[2]
;
Scremin, Jessica
[1]
;
Ceravolo, Graziela S.
[3]
;
Dekker, Robert F. H.
[4]
;
Barbosa-Dekker, Aneli M.
[5]
;
Teixeira, Marcos F. S.
[2]
;
Sartori, Elen R.
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Estadual Londrina, Ctr Ciencias Exatas, Dept Quim, Lab Eletroanalit & Sensores, BR-86057970 Londrina, PR - Brazil
[2] Univ Estadual Paulista UNESP, Fac Ciencias & Tecnol, Dept Quim & Bioquim, Presidents Prudente, SP - Brazil
[3] Univ Estadual Londrina, Ctr Ciencias Biol, Dept Fisiol, BR-86057970 Londrina, PR - Brazil
[4] Univ Tecnol Fed Parana, Programa Posgrad Engn Ambiental, Campus Londrina, BR-86036370 Londrina, PR - Brazil
[5] Univ Estadual Londrina, Ctr Ciencias Exatas, Dept Quim, BR-86057970 Londrina, PR - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Talanta; v. 210, APR 1 2020. |
| Web of Science Citations: | 1 |
| Abstract | |
The polysaccharide carboxymethyl-botryosphaeran (CMB) was used to improve the dispersion of multi-walled carbon nanotubes (MWCNTs) in water. This feature was applied in modifying a glassy carbon electrode (GCE) to construct a sensitive voltammetric sensor for the determination of desloratadine (DESL), a tricyclic antihistamine. The morphology and spectroscopic behavior of the sensor were evaluated. The modified sensor was characterized as homogeneous, and presented a higher electroactive area and a lower charge transfer resistance compared to the unmodified GCE. Using linear sweep voltammetry at 25 mV s(-1), the developed sensor presented a sensitivity of 1.018 mu A L mu mol(-1) in the linear working range of 1.99-32.9 mu mol L-1, with a detection limit of 0.88 mu mol L-1 of DESL in 0.10 mol L-1 potassium hydrogen-phosphate solution (pH 8.0). In addition, the sensor showed excellent repeatability with a relative standard deviation of only 1.02% for a sequence of 10 measurements. The sensor was successfully applied in the analysis of pharmaceutical preparations containing DESL, with equivalent results compared to a validated spectrophotometric method at the 95% confidence level. The sensor was also employed in the analysis of a spiked sample of DESL in rat serum. (AU) | |
| FAPESP's process: | 13/07296-2 - CDMF - Center for the Development of Functional Materials |
| Grantee: | Elson Longo da Silva |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |