| Texto completo | |
| Autor(es): |
Palo-Nieto, Carlos
[1]
;
Sau, Abhijit
[1]
;
Jeanneret, Robin
[1]
;
Payard, Pierre-Adrien
[2]
;
Salame, Aude
[2]
;
Martins-Teixeira, Maristela Braga
[3]
;
Carvalho, Ivone
[3]
;
Grimaud, Laurence
[2]
;
Galan, M. Carmen
[1]
Número total de Autores: 9
|
| Afiliação do(s) autor(es): | [1] Univ Bristol, Sch Chem, Bristol BS8 3TS, Avon - England
[2] Sorbonne Univ, Ecole Normale Super, CNRS, Lab Biomol LBM, F-75005 Paris - France
[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, BR-14040903 Monte Alegre do Sul - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ORGANIC LETTERS; v. 22, n. 5, p. 1991-1996, MAR 6 2020. |
| Citações Web of Science: | 1 |
| Resumo | |
We demonstrate that tuning the reactivity of Cu by the choice of oxidation state and counterion leads to the activation of both ``armed{''} and ``disarmed{''} type glycals toward direct glycosylation leading to the alpha-stereoselective synthesis of deoxyglycosides in good to excellent yields. Mechanistic studies show that Cu-I is essential for effective catalysis and stereocontrol and that the reaction proceeds through dual activation of both the enol ether as well as the OH nucleophile. (AU) | |
| Processo FAPESP: | 16/21194-6 - Síntese de derivados 2-desóxi glicosídicos de antraciclinas |
| Beneficiário: | Maristela Braga Martins Teixeira |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado |