The Influence of Environmental Cues on the Development of Trypanosoma cruzi in Triatominae Vector

Autor(es)

Melo, Raissa de Fatima Pimentel ^[1] ; Guarneri, Alessandra Aparecida ^[2] ; Silber, Ariel Mariano ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Lab Bioquim Tryps LaBTryps, Dept Parasitol, Inst Ciencias Biomed, Sao Paulo - Brazil

^[2] Fundacao Oswaldo Cruz, Vector Behaviour & Pathogen Interact Grp, Inst Rene Rachou, Belo Horizonte, MG - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY; v. 10, FEB 21 2020.
• Citações Web of Science: 10

Resumo

Trypanosoma cruzi, a hemoflagellate parasite, is the etiological agent of Chagas disease that affects about 6-7 million people worldwide, mostly in Latin America. The parasite life cycle is complex and alternates between an invertebrate host-Triatominae vector-and a mammalian host. The parasite adaptation to the several microenvironments through which it transits is critical to success in establishing infection. Moreover, environmental cues also play an important role on the parasite development, and it can modulate the infection. In the present study, we discussed how the temperature oscillations and the nutritional state of the invertebrate host can affect the parasite development, multiplication, and the differentiation process of epimastigote forms into metacyclic trypomastigotes, called metacyclogenesis. The impact of oxidative imbalance and osmotic stresses on the parasite-vector relationship are also discussed. (AU)

• Processo FAPESP: 16/06034-2 - O papel biológico de aminoácidos e seus metabólitos derivados em Trypanosoma cruzi
• Beneficiário: Ariel Mariano Silber
• Modalidade de apoio: Auxílio à Pesquisa - Temático