Association between craniofacial morphological patterns and tooth agenesis-related genes

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Rodrigues, Amanda Silva ^[1] ; Teixeira, Ellen Cardoso ^[2] ; Antunes, Leonardo Santos ^{[2, 3]} ; Nelson-Filho, Paulo ^[4] ; Cunha, Arthur Silva ^[4] ; Levy, Simone Carvalho ^[1] ; Araujo, Monica Tirre de Souza ^[5] ; Ramos, Alice Gomes de Carvalho ^[6] ; Cruz, Giuseppe Valduga ^[7] ; Omori, Marjorie Ayumi ^[4] ; Matsumoto, Mirian Aiko Nakane ^[4] ; Vieira, Alexandre Rezende ^[8] ; Kuchler, Erika Calvano ^{[4, 7]} ; Maranon-Vasquez, Guido Artemio ^[5] ; Antunes, Livia Azeredo Alves ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Fluminense Fed Univ, Sch Dent, Rua Sao Paulo 28, Campus Valonguinho, BR-24020150 Niteroi, RJ - Brazil

^[2] Fluminense Fed Univ, Sch Dent, Rua Doutor Silvio Henrique Braune 22, BR-28625650 Nova Friburgo, RJ - Brazil

^[3] Fluminense Fed Univ, Clin Res Unit, Rua Mario Santos Braga 30, BR-24020140 Niteroi, RJ - Brazil

^[4] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Pediat Dent, Ave Cafe S-N, Campus USP, BR-14040904 Ribeirao Preto, SP - Brazil

^[5] Univ Fed Rio de Janeiro, Sch Dent, Dept Pediat Dent & Orthodont, Rua Prof Rodolpho Paulo Rocco, 325 Cidade Univ, BR-21941617 Rio De Janeiro, RJ - Brazil

^[6] Amazonian Educ Inst, Rua Maceio 861, BR-69057010 Manaus, AM - Brazil

^[7] Positivo Univ, Dept Oral & Maxillofacial Surg, Rua Prof Pedro Viriato Parigot Souza 5300, BR-81200452 Curitiba, PR - Brazil

^[8] Univ Pittsburgh, Sch Dent Med, Dept Oral Biol, 412 Salk Pavil, 335 Sutherland St, Pittsburgh, PA 15261 - USA

• Tipo de documento: Artigo Científico
• Fonte: PROGRESS IN ORTHODONTICS; v. 21, n. 1 APR 6 2020.
• Citações Web of Science: 0

Resumo

Background The aim of the present study was to assess if genetic polymorphisms in tooth agenesis (TA)-related genes are associated with craniofacial morphological patterns. Methods This cross-sectional, multi-center, genetic study evaluated 594 orthodontic Brazilians patients. The presence or absence of TA was determined by analysis of panoramic radiography. The patients were classified according to their skeletal malocclusion and facial growth pattern by means of digital cephalometric analysis. Genomic DNA was extracted from squamous epithelial cells of buccal mucosa and genetic polymorphisms in MSX1 (rs1042484), PAX9 (rs8004560), TGF-alpha (rs2902345), FGF3 (rs1893047), FGF10 (rs900379), and FGF13 (rs12838463, rs5931572, and rs5974804) were genotyped by polymerase chain reaction using TaqMan chemistry and end-point analysis. Results Genotypes (p = 0.038) and allele (p = 0.037) distributions for the FGF3 rs1893047 were significantly different according to the skeletal malocclusion. Carrying at least one G allele increased in more than two times the chance of presenting skeletal class III malocclusion (OR = 2.21, CI 95% = 1.14-4.32; p = 0.017). There was no association between another skeletal craniofacial pattern and some polymorphism assessed in the present study. Conclusion Our results suggest that the genetic polymorphism rs1893047 in FGF3 might contribute to variations in the craniofacial sagittal pattern. (AU)

• Processo FAPESP: 16/08149-1 - Avaliação do papel do estrógeno nos tecidos dentofaciais
• Beneficiário: Erika Calvano Kuchler
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 15/06866-5 - Avaliação do papel do estrógeno no desenvolvimento dentofacial
• Beneficiário: Erika Calvano Kuchler
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores