Prognostication for oral squamous cell carcinoma patients based on the tumour-stroma ratio and tumour budding

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Dourado, Mauricio R. ^[1] ; Miwa, Karen Y. M. ^[1] ; Hamada, Guilherme B. ^[1] ; Paranaiba, Livia M. R. ^[2] ; Sawazaki-Calone, Iris ^[3] ; Domingueti, Catherine B. ^{[2, 4]} ; de Oliveira, Carine Ervolino ^[2] ; Furlan, Emylle C. B. ^[3] ; Longo, Bruna C. ^[3] ; Almangush, Alhadi ^{[5, 6]} ; Salo, Tuula ^{[7, 8, 9, 10]} ; Coletta, Ricardo D. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba 13414018, SP - Brazil

^[2] Fed Univ Alfenas UNIFAL MG, Inst Biomed Sci, Dept Pathol & Parasitol, Alfenas, MG - Brazil

^[3] Western Parana State Univ, Dent Sch, Cascavel, Oral Pathol & Oral Med, Cascavel, Parana - Brazil

^[4] Univ Jose Rosario Vellano UNIFENAS, Biomed, Varginha, MG - Brazil

^[5] Univ Helsinki, Dept Pathol, Helsinki - Finland

^[6] Univ Turku, Inst Biomed, Pathol, Turku - Finland

^[7] Univ Oulu, Oulu Univ Hosp, Med Res Ctr Oulu, Oulu - Finland

^[8] Univ Helsinki, Inst Oral & Maxillofacial Dis, Helsinki - Finland

^[9] Univ Oulu, Oulu Univ Hosp, Fac Med, Canc & Translat Med Res Unit, Oulu - Finland

^[10] Helsinki Univ Hosp, Dept Pathol, HUSLAB, Helsinki - Finland

• Tipo de documento: Artigo Científico
• Fonte: Histopathology; v. 76, n. 6 MAY 2020.
• Citações Web of Science: 0

Resumo

Aims Previous studies have demonstrated that the tumour-stroma ratio (TSR) and tumour budding are of prognostic value for oral squamous cell carcinomas (OSCCs). The aim of this study was to evaluate the prognostic significance of those histological parameters, individually and in combination, for OSCC. Methods and results The TSR and tumour budding (the presence of five or more buds at the invasive front) were estimated in 254 patients with OSCC. The clinicopathological association was investigated with a chi-square test, and the prognostic significance (cancer-specific survival and disease-free survival) was verified with Kaplan-Meier analysis and the Cox proportional hazard model. The TSR (>= 50%, stroma-rich) was significantly and independently associated with both shortened cancer-specific survival and poor disease-free survival, whereas tumour budding was significantly associated with reduced cancer-specific survival. The TSR/tumour budding model was independently associated with a high risk of cancer mortality and recurrence (disease-free survival). In patients with early-stage tumours (clinical stage I and II, n = 103), the TSR, tumour budding and the TSR/tumour budding model were significantly associated with both cancer-related death and recurrence, whereas, in advanced-stage tumours (clinical stage III and IV, n = 144), only the TSR and the TSR/tumour budding model were significantly associated with cancer-specific survival. Conclusions The TSR, tumour budding and their combination provide significant information on OSCC outcome, suggesting that their incorporation in the routine evaluation of histopathological specimens might be useful in prognostication for OSCC patients. (AU)

• Processo FAPESP: 17/26764-8 - Análise do valor prognóstico e papel biológico de proteínas superexpressas no carcinoma espinocelular oral identificadas por meio de proteômica baseada em espectrometria de massas
• Beneficiário: Mauricio da Rocha Dourado
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/16077-6 - Análise do Valor Prognóstico e Papel Biológico de Proteínas Superexpressas no Carcinoma de Células Escamosas Oral Identificadas por Meio de Proteômica Baseada em Espectrometria de Massas
• Beneficiário: Ricardo Della Coletta
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/16754-8 - Análise do valor prognóstico da proporção tumor-estroma no carcinoma epidermóide oral
• Beneficiário: Karen Yumie Mendonça Miwa
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 18/17689-5 - Validação do sistema de gradação histológica BD na prognosticação do carcinoma epidermóide oral
• Beneficiário: Guilherme Baptista Hamada
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica