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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Immobilization of L-alanine into natural kaolinite via amidation catalyzed by boric acid for the development of biohybrid materials

Texto completo
Autor(es):
da Silva, Alexandre Fernando [1] ; de Padua, Gabriel Silva [1] ; de Araujo, Denis Talarico [1] ; Vieira, Carlos Alexandre [1] ; de Faria, Emerson H. [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Franca, Grp Pesquisa Mat Lamelares Hibridos GPMatLam, Av Dr Armando Salles Oliveira, Parque Univ 201, BR-14404600 Franca, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Journal of Solid State Chemistry; v. 287, JUL 2020.
Citações Web of Science: 0
Resumo

The natural amino acid L-alanine was immobilized on the interlayer space and surface of the natural Brazilian Sao Simao's kaolinite using two different routes. In the first 3-aminopropyltriethoxysilane was previously grafted into kaolinite interlayer space resulting into aminofunctionlized kaolinite that was further employed as reactive sites on kaolinite surfaces to bond L-alanine via amidation reaction. In the second route 3-aminopropyltriethoxysilane was first modified by L-alanine via amidation reaction catalyzed by boric acid and the modified alkoxide grafted into kaolinite using kaolinite-dimethylsulfoxide resulting on the biohybrid. In both strategies the amino acid was covalently bounded using the carboxylic acid from the amino acids and amine groups present on the kaolinite surfaces resulting in amide bonds. In both routes, the reaction was catalyzed by boric acid. Results confirms that the nature and loading of immobilized L-alanine changes depending of the route employed. X-ray diffraction confirmed the expansion of the interlayer spaces of the grafted solids resulting in 8.3 angstrom and 10.8 angstrom respectively for grafted materials routes one and two respectively. Reaction effectivity was kinetically evaluated by infrared vibrational spectroscopy that confirms the presence of amide bonds in both products due to the bands at 1560 cm(-1) , due to carbonyl (N-C=O) stretching, and 1490 cm(-1) , ascribed to N-H plane vibrations and C-N stretching. The typical vibration of inner surface aluminol groups at 938 cm(-1) (for purified kaolinite) is absent for both routes employed after grafting reactions confirming the attachment of the modified alkoxide into aluminol groups via covalent bonds resulting in bonds type Al-O-Si. Thermal analysis showed the typical reduction of dehydroxylation temperature from 510 degrees C on pure kaolinite to 480 and 450 degrees C, respectively, on the biohybrid materials and confirmed the functionalization in both routes, the amount of organic content was quantified and was 0.193 and 0.298 mol of organic unit per 1 mol of kaolinite minimal formulae using route of previous grafting of kaolinite with amine groups and direct grafting of modified alkoxide into kaolinite dimethyl sulfoxide respectively. Specific surface area analysis by N-2 adsorption-desorption isotherms (BET method), cationic exchange capacity, and total specific surface area by the methylene blue method also confirmed the reduction of specific surface area from kaolinite grafted derivatives induced by amidation reaction. The solids obtained was tested as matrix to incorporate acetyl salicylic acid and ibuprofen and reveal that grafted clays incorporate a higher amount of both drugs (qt = 210 mg/g) The model that explain the adsorption kinetic mechanism was the pseudo-second order that reveal the higher affinity between adsorbent and acetyl salicilSalicylic acid and ibuprofen using the grafted kaolinite with alanine. (AU)

Processo FAPESP: 98/11022-3 - Oxidação catalítica biomimética
Beneficiário:Katia Jorge Ciuffi Pires
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/19523-3 - Materiais biohíbridos funcionais baseados em argilas lamelares e/ou fibrosas com aplicações multifacetadas
Beneficiário:Emerson Henrique de Faria
Linha de fomento: Auxílio à Pesquisa - Regular
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Linha de fomento: Auxílio à Pesquisa - Regular
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Beneficiário:Eduardo José Nassar
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Processo FAPESP: 17/15482-1 - Novas estratégias para o reaproveitamento de subprodutos de curtumes para a obtenção de materiais porosos funcionais de alto valor agregado
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Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/01501-1 - Catalisadores multifuncionais para processos oxidativos avançados empregando matrizes biogênicas ou argilas
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Linha de fomento: Auxílio à Pesquisa - Regular