OMEGA-3 Interventions in Alcohol Dependence and Related Outcomes: A Systematic Review and Propositions

Autor(es)

Galduroz, Jose Carlos F. ^[1] ; Bezerra, Andreia Gomes ^[1] ; Pires, Gabriel Natan ^{[1, 2]} ; Pauluci, Renata ^[1] ; Noto, Ana Regina ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil

^[2] Santa Casa Sao Paulo Sch Med Sci, Dept Physiol Sci, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Current Neuropharmacology; v. 18, n. 5, p. 456-462, 2020.
• Citações Web of Science: 0

Resumo

Background: Pharmacological treatment for alcohol dependence has only three approved drugs: disulfiram, naltrexone and acamprosate. The effects of these drugs are, however, limited, presenting several side effects and a modestly higher efficacy compared to placebo. The administration of omega-3 might bring new perspectives to relapse prevention. Methods: This systematic review aimed to analyze the available literature, compiling the studies that used omega-3 to prevent relapse in alcohol dependents. Results: The databases used were PubMed and Web of Science. We identified 2,231 studies and only five articles addressed the administration of omega-3 and alcoholism. Preclinical studies evaluating the effects of PUFAs related to chronic alcohol administration showed improvements in behavioral, cellular and molecular levels. The clinical trial yielded inconclusive results. Conclusion: Despite the reduced number of studies, omega-3 interventions seem to be promising for controlling issues related to alcohol dependence. (AU)

• Processo FAPESP: 15/19472-5 - Intervenções inovadoras frente a problemas relacionados ao consumo do álcool no Brasil: busca de novas abordagens para uma antiga questão de saúde pública
• Beneficiário: Ana Regina Noto
• Modalidade de apoio: Auxílio à Pesquisa - Temático