The dorsal subiculum is required for contextual fear conditioning consolidation in rats

Autor(es)

de Melo, Marcio Braga ^[1] ; Favaro, Vanessa Manchim ^[1] ; Menezes Oliveira, Maria Gabriela ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Behavioural Brain Research; v. 390, JUL 15 2020.
• Citações Web of Science: 0

Resumo

The hippocampal formation has a well-known role in contextual fear conditioning. The dorsal subiculum connects the hippocampus to the entorhinal cortex through pathways that seemingly rely on NMDA-dependent synaptic plasticity. The role of the dorsal subiculum in contextual fear conditioning retrieval, but not acquisition, has been previously reported. However, most of the critical biological phenomena involved in memory formation occur in the consolidation phase. The present study aimed to assess the effects of intra-dorsal subiculum muscimol or AP5 infusion on contextual fear conditioning consolidation. Our data show that dorsal subiculum integrity, as well as NMDA transmission in this region, seem to be necessary for contextual fear conditioning consolidation. (AU)

• Processo FAPESP: 17/09837-1 - Envolvimento dos sistemas glutamatérgico e gabaérgico no subículo dorsal sobre os processos de aquisição e consolidação de memória em tarefas de aprendizagem aversiva em ratos
• Beneficiário: Márcio Braga de Melo
• Modalidade de apoio: Bolsas no Brasil - Mestrado