Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The dorsal subiculum is required for contextual fear conditioning consolidation in rats

Full text
Author(s):
de Melo, Marcio Braga [1] ; Favaro, Vanessa Manchim [1] ; Menezes Oliveira, Maria Gabriela [1]
Total Authors: 3
Affiliation:
[1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Behavioural Brain Research; v. 390, JUL 15 2020.
Web of Science Citations: 0
Abstract

The hippocampal formation has a well-known role in contextual fear conditioning. The dorsal subiculum connects the hippocampus to the entorhinal cortex through pathways that seemingly rely on NMDA-dependent synaptic plasticity. The role of the dorsal subiculum in contextual fear conditioning retrieval, but not acquisition, has been previously reported. However, most of the critical biological phenomena involved in memory formation occur in the consolidation phase. The present study aimed to assess the effects of intra-dorsal subiculum muscimol or AP5 infusion on contextual fear conditioning consolidation. Our data show that dorsal subiculum integrity, as well as NMDA transmission in this region, seem to be necessary for contextual fear conditioning consolidation. (AU)

FAPESP's process: 17/09837-1 - Involvement of the glutamatergic and gabaergic systems in the dorsal subiculum on the processes of acquisition and memory consolidation in aversive learning tasks in rats
Grantee:Márcio Braga de Melo
Support Opportunities: Scholarships in Brazil - Master