Clinicopathological analysis of oral Burkitt's lymphoma in pediatric patients: A systematic review

Autor(es)

Rodrigues-Fernandes, Carla Isabelly ^[1] ; Perez-de-Oliveira, Maria Eduarda ^[1] ; Aristizabal Arboleda, Lady Paola ^[1] ; Fonseca, Felipe Paiva ^{[1, 2, 3]} ; Lopes, Marcio Ajudarte ^[1] ; Vargas, Pablo Agustin ^{[1, 3]} ; Santos-Silva, Alan Roger ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Semiol & Oral Pathol Areas, Ave Limeira 901, BR-13414903 Piracicaba, SP - Brazil

^[2] Univ Fed Minas Gerais, Sch Dent, Dept Oral Surg & Pathol, BR-31270901 Belo Horizonte, MG - Brazil

^[3] Univ Pretoria, Dept Oral Biol & Oral Pathol, Pretoria - South Africa

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Pediatric Otorhinolaryngology; v. 134, JUL 2020.
• Citações Web of Science: 0

Resumo

The aim of this study was to integrate the available data regarding pediatric Burkitt's lymphoma (BL) of the oral cavity. A systematic review was conducted following PRISMA guidelines, through a specific search strategy. Twenty-nine publications were included in this study, resulting in a total of 144 cases. Oral BL was predominantly found in males (75.7%). The mandible was the most involved site (37.5%), and all cases clinically exhibited a swelling. Presence of EBV was observed in 33.3% of the cases, and 4 cases reported HIV-positive patients (33.3%). Chemotherapy was the leading treatment choice for oral BL (94.9%), and the overall 5-year survival was 54.3%. Regarding the quality assessment of the studies, most (19 studies; 65.5%) were classified as an overall moderate risk of bias. In conclusion, the clinicopathological characteristics of oral BL in the pediatric population comprise the sporadic and intermediate subtypes. Despite its aggressiveness, this malignancy presents a moderate overall survival. (AU)

• Processo FAPESP: 17/14880-3 - Análise clinicopatológica e imunoistoquímica das hiperplasias linfoides foliculares e dos linfomas da cavidade oral
• Beneficiário: Oslei Paes de Almeida
• Modalidade de apoio: Auxílio à Pesquisa - Regular