Facial Squamous Cell Carcinoma and Abdominal Peripheral Nerve Sheath Tumour with Rhabdomyoblastic Differentiation in a Rough-toothed Dolphin (Steno bredanensis)

Autor(es)

Alves-Motta, M. R. ^{[1, 2]} ; Luz-Carvalho, V ^[2] ; Nunes-Pinheiro, D. C. S. ^[1] ; Groch, K. R. ^[3] ; Goncalves-Pereira, L. ^[2] ; Sanchez-Sarmiento, A. M. ^[3] ; Sacristan, C. ^[3] ; Catao-Dias, J. L. ^[3] ; Diaz-Delgado, J. ^{[3, 4]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Ceara, Programa Posgrad Ciencias Vet, Fortaleza, Ceara - Brazil

^[2] Assoc Pesquisa & Preservacao Ecossistemas Aquat, Iparana, Caucaia - Brazil

^[3] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Patol, Sao Paulo - Brazil

^[4] Texas A&M Vet Med Diagnost Lab, 483 Agron Rd, College Stn, TX 77843 - USA

• Tipo de documento: Artigo Científico
• Fonte: Journal of Comparative Pathology; v. 176, p. 122-127, APR 2020.
• Citações Web of Science: 0

Resumo

We report the pathological features of a facial squamous cell carcinoma (SCC) and an abdominal peripheral nerve sheath tumour (PNST) with rhabdomyoblastic differentiation in an aged free-ranging rough-toothed dolphin (Steno bredanensis). The animal was found stranded dead in poor body condition. On external examination, there was a 25 x 7 x 3 cm extensively ulcerated area on the right maxillary region of the rostrum, involving the oral mucocutaneous junction with prominent nodular edges, severe soft tissue loss and extensive maxillary and premaxillary bone lysis. On abdominal dissection, a 5 x 4 x 3.5 cm pale tan to red, raised mass expanded the inner aspect of the right transverse abdominis muscle. Microscopically, the aggressive facial lesion was an acantholytic SCC with extensive osteolysis; there was no evidence of metastasis in the tissues examined. The abdominal mass had cytohistomorphological features compatible with a localized PNST, including whorling, Antoni A and Antoni B areas and Verocay bodies intermixed with rhabdomyoblastic components, as suggested by phosphotungstic acid haematoxylin stain. This neoplasm was locally infiltrative, yet no metastases were observed in the tissues examined. No immunohistochemical investigations could be performed due to lack of tissue availability. Total DNA from the formalin-fixed and paraffin wax-embedded SCC was extracted and tested by polymerase chain reaction for herpesvirus and papillomavirus genetic material. There was no amplification for either of these genera. Other pathological findings observed in this animal were related to the `live-stranding stress response'. The severity and extent of the facial SCC likely related to anorexia and poor body condition and might have played a role in the stranding and death of this dolphin. These two tumour subtypes add to the relatively uncommon reports of neoplasia in cetaceans. Specifically, these appear to be the first neoplasia records for rough-toothed dolphins, including the first documentation of a PNST with features compatible with rhabdomyoblastic differentiation in a marine mammal. (C) 2020 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 18/25069-7 - Estudo e caracterização de agentes virais emergentes selecionados e potencialmente associados a hepatopatias em cetáceos costeiros, pelágicos e de habitat misto no Brasil
• Beneficiário: Carlos Sacristan Yague
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/02223-8 - Imunopatologia comparativa da infecção por Morbillivirus nos cetáceos: estudos histológico, imuno-histoquímico e molecular
• Beneficiário: Josué Díaz Delgado
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado