KLOTHO polymorphisms and age-related outcomes in community-dwelling older subjects: The SAo Paulo Ageing & Health (SPAH) Study

Autor(es):Mostrar menos -

Pereira, Rosa Maria R. ^[1] ; Freitas, Thiago Quadrante ^{[1, 2]} ; Franco, Andre Silva ^{[1, 2]} ; Takayama, Liliam ^{[1, 2]} ; Caparbo, Valeria F. ^{[1, 2]} ; Domiciano, Diogo S. ^{[1, 2]} ; Machado, Luana G. ^{[1, 2]} ; Figueiredo, Camille P. ^{[1, 2]} ; Menezes, Paulo R. ^[3] ; Onuchic, Luiz Fernando ^{[1, 4, 5]} ; de Castro, Isac ^{[4, 5]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med FMUSP, Rheumatol Div, Bone Metab Lab, Sao Paulo, SP - Brazil

^[2] de Castro, Isac, Univ Sao Paulo, Fac Med FMUSP, Div Nephrol, Sao Paulo, SP, Brazil.Pereira, Rosa Maria R., Univ Sao Paulo, Fac Med FMUSP, Rheumatol Div, Bone Metab Lab, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Fac Med FMUSP, Dept Prevent Med, Sao Paulo, SP - Brazil

^[4] Univ Sao Paulo, Fac Med FMUSP, Div Mol Med, Sao Paulo, SP - Brazil

^[5] Univ Sao Paulo, Fac Med FMUSP, Div Nephrol, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 10, n. 1 MAY 22 2020.
• Citações Web of Science: 0

Resumo

Defective KLOTHO gene expression in mice led to a syndrome resembling human ageing. This study evaluated three KLOTHO polymorphisms, namely G395A, C1818T, and C370S, in an elderly population (mean age of 73 years) and their associations with ageing-related outcomes (cardiovascular events, kidney function, osteoporosis, sarcopenia) and mortality. Estimated glomerular filtration rates (eGFR) was lower in subjects with 1818TT (P=0.047) and 370SS (P=0.046) genotypes. The 1818TT genotype (P=0.006) and 1818T allele were associated with higher frequency of myocardial infarction (MI) (CC:1.7% vs. CT+TT:7.0%; P=0.002). The 370SS genotype was associated with lower stroke frequency (P=0.001). MI (OR 3.35 {[}95% CI: 1.29-8.74]) and stroke (OR 3.64 {[}95% CI: 1.48-8.97]) were associated with mortality. Regarding MI, logistic regression showed 1818T allele was a risk factor for death-related MI (OR 4.29 {[}95% CI: 1.60-11.52]; P=0.003), while 370C was protective (OR 0.03 {[}95% CI: 0.01-0.08]; P<0.001). Regarding stroke, the 395A and 370C alleles were protective factors (respectively: OR 0.28 {[}95% CI: 0.20-0.80]; P=0.018; OR 0.10 {[}95% CI: 0.05-0.18]; P<0.001). This is the first study to determine potential associations between common ageing-related outcomes/mortality and KLOTHO polymorphisms. The 1818T allele was a risk factor for MI-related death. The 395A and 370C alleles were protective factors for stroke-related death in elderly from community. (AU)

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