| Full text | |
| Author(s): Show less - |
Pereira, Rosa Maria R.
[1]
;
Freitas, Thiago Quadrante
[1, 2]
;
Franco, Andre Silva
[1, 2]
;
Takayama, Liliam
[1, 2]
;
Caparbo, Valeria F.
[1, 2]
;
Domiciano, Diogo S.
[1, 2]
;
Machado, Luana G.
[1, 2]
;
Figueiredo, Camille P.
[1, 2]
;
Menezes, Paulo R.
[3]
;
Onuchic, Luiz Fernando
[1, 4, 5]
;
de Castro, Isac
[4, 5]
Total Authors: 11
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med FMUSP, Rheumatol Div, Bone Metab Lab, Sao Paulo, SP - Brazil
[2] de Castro, Isac, Univ Sao Paulo, Fac Med FMUSP, Div Nephrol, Sao Paulo, SP, Brazil.Pereira, Rosa Maria R., Univ Sao Paulo, Fac Med FMUSP, Rheumatol Div, Bone Metab Lab, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Fac Med FMUSP, Dept Prevent Med, Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Fac Med FMUSP, Div Mol Med, Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Fac Med FMUSP, Div Nephrol, Sao Paulo, SP - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 10, n. 1 MAY 22 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Defective KLOTHO gene expression in mice led to a syndrome resembling human ageing. This study evaluated three KLOTHO polymorphisms, namely G395A, C1818T, and C370S, in an elderly population (mean age of 73 years) and their associations with ageing-related outcomes (cardiovascular events, kidney function, osteoporosis, sarcopenia) and mortality. Estimated glomerular filtration rates (eGFR) was lower in subjects with 1818TT (P=0.047) and 370SS (P=0.046) genotypes. The 1818TT genotype (P=0.006) and 1818T allele were associated with higher frequency of myocardial infarction (MI) (CC:1.7% vs. CT+TT:7.0%; P=0.002). The 370SS genotype was associated with lower stroke frequency (P=0.001). MI (OR 3.35 {[}95% CI: 1.29-8.74]) and stroke (OR 3.64 {[}95% CI: 1.48-8.97]) were associated with mortality. Regarding MI, logistic regression showed 1818T allele was a risk factor for death-related MI (OR 4.29 {[}95% CI: 1.60-11.52]; P=0.003), while 370C was protective (OR 0.03 {[}95% CI: 0.01-0.08]; P<0.001). Regarding stroke, the 395A and 370C alleles were protective factors (respectively: OR 0.28 {[}95% CI: 0.20-0.80]; P=0.018; OR 0.10 {[}95% CI: 0.05-0.18]; P<0.001). This is the first study to determine potential associations between common ageing-related outcomes/mortality and KLOTHO polymorphisms. The 1818T allele was a risk factor for MI-related death. The 395A and 370C alleles were protective factors for stroke-related death in elderly from community. (AU) | |
| FAPESP's process: | 11/00411-5 - Incidence of vertebral fractures and non-vertebral clinical fractures in a population of individuals age 65 or more |
| Grantee: | Diogo Souza Domiciano |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 03/09313-0 - Prevalence of osteoporosis, vertebral and non-vertebral fractures in a female population aged 65 or older in the Butantã area |
| Grantee: | Rosa Maria Rodrigues Pereira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 09/15346-4 - Incidence of vertebral fractures and non-vertebral clinical fractures in a population of individuals aged 65 or more |
| Grantee: | Rosa Maria Rodrigues Pereira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 04/12694-8 - Incidence of dementia and cognitive decline in low-income elderly in São Paulo: a cohort study |
| Grantee: | Isabela Judith Martins Bensenor |
| Support Opportunities: | Regular Research Grants |