Neuropsychiatric feature profiles of patients with Lewy body dementia

Autor(es)

de Oliveira, Fabricio Ferreira ^[1] ; Machado, Fernando Chiodini ^{[1, 2]} ; Sampaio, Gustavo ^{[1, 2]} ; Correia Marin, Sheilla de Medeiros ^{[1, 2]} ; Naffah-Mazzacoratti, Maria da Graca ^{[1, 2]} ; Ferreira Bertolucci, Paulo Henrique ^[2]

Afiliação do(s) autor(es)

^[1] Fed Univ Sao Paulo UNIFESP, Dept Neurol & Neurosurg, Escola Paulista Med, Sao Paulo, SP - Brazil

^[2] Ferreira Bertolucci, Paulo Henrique, Fed Univ Sao Paulo UNIFESP, Dept Neurol \& Neurosurg, Escola Paulista Med, Sao Paulo, SP, Brazil.de Oliveira, Fabricio Ferreira, Fed Univ Sao Paulo UNIFESP, Dept Neurol & Neurosurg, Escola Paulista Med, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL NEUROLOGY AND NEUROSURGERY; v. 194, JUL 2020.
• Citações Web of Science: 0

Resumo

Objective: Differential diagnosis between Parkinson's disease (PD) dementia and dementia with Lewy bodies (DLB) is difficult due to common features, whereas management decisions and research endpoints depend upon knowledge of dementia severity. We aimed to assess risk factors for age at dementia onset, as well as which neuropsychiatric features are associated with pharmacotherapy and signs and symptoms of Lewy body dementia. Patients and methods: Patients with PD dementia or DLB were evaluated for age at disease onset, education, sanitation, anthropometric measures, alcohol use, smoking, history of infections or head trauma with unconsciousness, family history of neurodegenerative diseases, functional independence, cognition, behavior, motor features, caregiver burden and pharmacotherapy. Results: Fifty-one patients were recruited (37 with DLB, 14 with PD dementia). Cumulative alcohol use and married status were associated with earlier dementia onset, whereas history of treated systemic infections and cumulative family history of primary neurodegenerative diseases led to later dementia onset. The length of dementia was shorter only for severely impaired patients who used anti-depressants, but not for users of cholinesterase inhibitors, while no behavioral symptom was associated with dopaminergic therapy. Night-time behavior disturbances were inversely associated with sleep satisfaction, while caregiver burden was more affected by depression and motor features. Non-motor symptoms were more burdensome for patients with DLB, while in PD dementia anxiety and dysphoria occurred when motor features were less burdensome. Conclusions: PD dementia and DLB are two phenotypes of the same pathological entity, differing mostly by the occurrence of parkinsonian signs. Predictors of dementia onset differ from other neurodegenerative diseases. (AU)

• Processo FAPESP: 15/10109-5 - Análise comparativa de marcadores liquóricos e séricos na demência com corpúsculos de Lewy e na demência da Doença de Alzheimer
• Beneficiário: Fabricio Ferreira de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado