Multicomponent Training Changes Blood Pressure and Redox Status in Older Women: Influence of beta(2) Adrenergic Receptor Haplotypes

Autor(es)

Porto Goncalves, Thiago Correa ^[1] ; Trape, Atila Alexandre ^[2] ; Lima Rodrigues, Jhennyfer Aline ^[2] ; Tavares, Simone Sakagute ^{[3, 1]} ; Bueno Junior, Carlos Roberto ^{[3, 1, 2, 4]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Ribeirao Preto - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Coll Nursing, Ribeirao Preto - Brazil

^[3] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, Ribeirao Preto - Brazil

^[4] Bueno Junior, Carlos Roberto, Univ Sao Paulo, Sch Phys Educ \& Sport Ribeirao Preto, Ribeirao Preto, Brazil.Porto Goncalves, Thiago Correa, Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Ribeirao Preto - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF AGING AND PHYSICAL ACTIVITY; v. 28, n. 2, p. 242-249, APR 2020.
• Citações Web of Science: 0

Resumo

The beta(2) adrenergic receptor (beta(2)-AR) plays an important role in vascular smooth muscle. However, the interaction between Arg16Gly and Gln27Glu beta(2)-AR polymorphisms, and exercise training has not yet been established. This study evaluated the influence of these beta(2)-AR polymorphisms on body composition, aerobic capacity, blood pressure, lipid profile, nitric oxide, and redox status at baseline and in response to an exercise program in women aged 50-79 years. Genotype and haplotypes were analyzed in association with the previously mentioned variables before and after the multicomponent training (12 weeks, 2 sessions/week, 90 min/session, and exercise intensity between 13 and 15 on the Borg scale). Individuals who carry beta(2)-AR Arg16Arg/Gln27Gln genotypes presented more improvements in blood pressure, body composition, aerobic capacity, and redox status in response to a multicomponent training program compared with individuals who do not carry this haplotype. In some years, the genetic profile may be used to predict which exercise program can induce more health benefits for each person. (AU)

• Processo FAPESP: 13/21159-8 - Influência de polimorfismos genéticos nos efeitos de dois tipos de treinamento físico aeróbio intervalado de alta intensidade em indivíduos com síndrome metabólica
• Beneficiário: Carlos Roberto Bueno Júnior
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/21361-2 - Screening global de fatores genéticos e epigenéticos associados com magnitude de resposta a diferentes treinamentos físicos em mulheres de 50 a 70 anos
• Beneficiário: Carlos Roberto Bueno Júnior
• Modalidade de apoio: Auxílio à Pesquisa - Regular