Latitudinal diversity gradient and cetaceans from the perspective of MHC genes

Autor(es)

Andreani, Maria Luiza ^[1] ; Nery, Mariana F. ^[4]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas UNICAMP, Dept Genet Evolucao Microbiol & Imunol, Lab Genom Evolut, Inst Biol, Rua Monteiro Lobato, 255, Cidade Univ, IB, Bloco H, BR-13083862 Campinas, SP - Brazil

^[2] Nery, Mariana F., Univ Estadual Campinas UNICAMP, Dept Genet Evolucao Microbiol \& Imunol, Lab Genom Evolut, Inst Biol, Rua Monteiro Lobato,255,Cidade Univ,IB,Bloco H, BR-13083862 Campinas, SP, Brazil.Andreani, Maria Luiza, Univ Estadual Campinas UNICAMP, Dept Genet Evolucao Microbiol & Imunol, Lab Genom Evolut, Inst Biol, Rua Monteiro Lobato, 255, Cidade Univ, IB, Bloco H, BR-13083862 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: IMMUNOGENETICS; v. 72, n. 6-7 JUN 2020.
• Citações Web of Science: 0

Resumo

Pathogen diversity is a key source of selective pressure on immune system genes, shaping molecular evolution mainly on widely distributed or migratory organisms such as cetaceans. Here, we investigated the effects of latitudinal span migration, different biomes occupation, and pathogen-mediated selection on MHC DQB locus divergence on cetaceans. We applied some evolutionary genetics methods using a dataset of 15 species and 121 sequences, and we found a trend on greater MHC divergence on tropical species when compared with either temperate or migratory species. In addition, oceanic cetaceans exhibit greater MHC divergence. Here, we show that, despite there was a correlation between the diversity of MHC DQB alleles with the distribution of organisms, the pattern of diversity found is not completely explained by pathogenic pressure, suggesting that other factors must be investigated for a better understanding of the processes related to the diversity of MHC in cetaceans. (AU)

• Processo FAPESP: 15/18269-1 - Usando genômica comparativa para entender a evolução convergente de mamíferos: em busca das pegadas moleculares da ocupação do ambiente marinho e fluvial
• Beneficiário: Mariana Freitas Nery
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores