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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Green Propolis: Cytotoxic and Leishmanicidal Activities of Artepillin C,p-Coumaric Acid, and Their Degradation Products

Texto completo
Autor(es):
Arruda, Caroline [1] ; Ribeiro, Victor Pena [1, 2] ; Mejia, Jennyfer Andrea Aldana [1, 2] ; Almeida, Marilia Oliveira [1, 2] ; Goulart, Mirian Oliveira [3, 1] ; Candido, Ana Carolina Bolela Bovo [3, 1] ; dos Santos, Raquel Alves [3, 1] ; Magalhaes, Lizandra Guidi [3, 1] ; Martins, Carlos Henrique Gomes [3] ; Bastos, Jairo Kenupp [1, 2]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Ave Cafe S-N, BR-14040930 Ribeirao Preto, SP - Brazil
[2] Martins, Carlos Henrique Gomes, Univ Franca, Ave Dr Armando Salles de Oliveira 201, BR-14404600 Franca, SP, Brazil.Arruda, Caroline, Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Ave Cafe S-N, BR-14040930 Ribeirao Preto, SP - Brazil
[3] Univ Franca, Ave Dr Armando Salles de Oliveira 201, BR-14404600 Franca, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 30, n. 2, p. 169-176, APR 2020.
Citações Web of Science: 4
Resumo

Brazilian green propolis is a bee product which displays many biological activities, such as antiparasitic, antimicrobial, and cytotoxic. Artepillin C andp-coumaric acid are two of its major compounds that contribute to these activities. Both compounds were submitted to degradation under light, oxygen, and heating, furnishing four and one degradation products, respectively. Artepillin C,p-coumaric acid, and their degradation products were evaluated against seven strains of oral bacteria, cancer cell lines (AGP-01 and He-La), andLeishmania amazonensis(promastigotes and amastigotes). TheZ-isomer artifact of artepillin C displayed significant activity against both gastric cancer cell line AGP-01 (IC(50)9.09 mu M) andL. amazonensis, especially against the amastigote forms of the parasite (IC(50)3.49 mu M).p-Coumaric acid also displayed a promising activity againstL. amazonensisamastigotes (IC(50)3.12 mu M), while itsZ-isomer artifact was more effective against the promastigotes (IC(50)9.35 mu M). The obtained compounds were not cytotoxic against the normal cell line CHO-k1. The present study shows that Brazilian green propolis is an important source of bioactive compounds and thatZ-artepillin C andZ-p-coumaric acid display antiparasitic and cytotoxic activities. (AU)

Processo FAPESP: 17/04138-8 - Realização de estudos químicos, analíticos, biológicos, farmacológicos e tecnológicos para preenchimento das lacunas no desenvolvimento do setor de própolis brasileiro
Beneficiário:Jairo Kenupp Bastos
Modalidade de apoio: Auxílio à Pesquisa - Temático