CD1a+and CD207+cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma

Autor(es)

da Silva, Luan Cesar ^[1] ; Fonseca, Felipe Paiva ^[2] ; de Almeida, Oslei Paes ^{[1, 3]} ; Linhares de Almeida Mariz, Bruno Augusto ^{[1, 3]} ; Lopes, Marcio Ajudarte ^{[1, 3]} ; Radhakrishnan, Raghu ^[4] ; Sharma, Mohit ^[5] ; Kowalski, Luiz Paulo ^[6] ; Vargas, Pablo Agustin ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, SP - Brazil

^[2] Univ Minas Gerais, Sch Dent, Dept Oral Surg & Pathol, Belo Horizonte, MG - Brazil

^[3] Kowalski, Luiz Paulo, AC Camargo Canc Ctr, Dept Head \& Neck Surg \& Otorhinolaryngol, Sao Paulo, Brazil.da Silva, Luan Cesar, Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, SP - Brazil

^[4] Manipal Acad Higher Educ, Dept Oral Pathol & Microbiol, Manipal - India

^[5] Sudha Rustagi Coll Dent Sci & Res, Dept Oral Pathol, Faridabad - India

^[6] AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL; v. 25, n. 1, p. E49-E55, JAN 2020.
• Citações Web of Science: 1

Resumo

Background: The objective of this study investigated the distribution of immature dendritic cells (DCs), Langerhans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). Material and Methods: Fourteen cases of OSMF, 9 of OSMF-OSCC, 8 of OL, 45 of OSCC and 8 of normal epithelium were retrospectively retrieved and their diagnoses confirmed. Immunoreactions against CD1a, CD207 e CD303 were performed and the number of positive cells quantified. Results: A significant decrease of CD1a+ was found in OSMF (p <= 0.05), OSMF-OSCC (p <= 0.01), and OSCC (p <= 0.001) when compared to normal epithelium. For CD207+ the significance decrease was observed in OSMF-OSCC (p <= 0.05), and OSCC (p <= 0.01) when compared with normal epithelium, and in OSMF when compared with OL (p <= 0.05). There was no significant difference for CD303, but increased in CD303+ was observed in OSCC when compared with normal epithelium. Conclusion: The decrease in the number of CD1a+ and CD207+ cells may be associate to the development of oral OSCC, and in OPMDs they might be indicators of malignant transformation. (AU)

• Processo FAPESP: 17/15633-0 - Estudo da imunoexpressão de marcadores de células de Langerhans em fibrose submucosa oral
• Beneficiário: Luan César da Silva
• Modalidade de apoio: Bolsas no Brasil - Mestrado