Multiangle Long-Axis Lateral Illumination Photoacoustic Imaging Using Linear Array Transducer

Autor(es)

Uliana, Joao H. ^[1] ; Sampaio, Diego R. T. ^[1] ; Fernandes, Guilherme S. P. ^[1] ; Brassesco, Maria S. ^[2] ; Nogueira-Barbosa, Marcello H. ^[3] ; Carneiro, Antonio A. O. ^[1] ; Pavan, Theo Z. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Phys, FFCLRP, BR-14040901 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Dept Biol, FFCLRP, BR-14040901 Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Med Images Hematol & Clin Oncol, BR-14040901 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SENSORS; v. 20, n. 14 JUL 2020.
• Citações Web of Science: 0

Resumo

Photoacoustic imaging (PAI) combines optical contrast with ultrasound spatial resolution and can be obtained up to a depth of a few centimeters. Hand-held PAI systems using linear array usually operate in reflection mode using a dark-field illumination scheme, where the optical fiber output is attached to both sides of the elevation plane (short-axis) of the transducer. More recently, bright-field strategies where the optical illumination is coaxial with acoustic detection have been proposed to overcome some limitations of the standard dark-field approach. In this paper, a novel multiangle long-axis lateral illumination is proposed. Monte Carlo simulations were conducted to evaluate light delivery for three different illumination schemes: bright-field, standard dark-field, and long-axis lateral illumination. Long-axis lateral illumination showed remarkable improvement in light delivery for targets with a width smaller than the transducer lateral dimension. A prototype was developed to experimentally demonstrate the feasibility of the proposed approach. In this device, the fiber bundle terminal ends are attached to both sides of the transducer's long-axis and the illumination angle of each fiber bundle can be independently controlled. The final PA image is obtained by the coherent sum of subframes acquired using different angles. The prototype was experimentally evaluated by taking images from a phantom, a mouse abdomen, forearm, and index finger of a volunteer. The system provided light delivery enhancement taking advantage of the geometry of the target, achieving sufficient signal-to-noise ratio at clinically relevant depths. (AU)

• Processo FAPESP: 17/14482-8 - Redução de artefatos para geração de imagem híbrida ultrassom/fotoacústica
• Beneficiário: Guilherme Santos Pilotto Fernandes
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 16/22374-8 - Análise da oxigenação sanguínea em tumores por meio de imagens fotoacústicas.
• Beneficiário: João Henrique Uliana
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/18854-6 - Imagens fotoacústicas e ultrassônicas para caracterização de tecidos viscoelásticos
• Beneficiário: Theo Zeferino Pavan
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 15/05684-0 - Formação de imagem fotoacústica induzida por laser e raios-X
• Beneficiário: Diego Ronaldo Thomaz Sampaio
• Modalidade de apoio: Bolsas no Brasil - Doutorado