The Value of Cardiopulmonary Exercise Testing in Determining Severity in Patients with both Systolic Heart Failure and COPD

Autor(es):Mostrar menos -

Goulart, Cassia Luz ^[1] ; dos Santos, Polliana Batista ^[1] ; Caruso, Flavia Rossi ^[1] ; Tinoco Areas, Guilherme Peixoto ^[1] ; Marinho, Renan Shida ^[1] ; Camargo, Patricia de Faria ^[1] ; Alexandre, Tiago Silva ^[2] ; Oliveira, Claudio R. ^[1] ; Goncalves da Silva, Andrea Lucia ^[3] ; Mendes, Renata Goncalves ^[1] ; Roscani, Meliza Goi ^[4] ; Borghi-Silva, Audrey ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Physiotherapy Dept, Cardiopulm Physiotherapy Lab, UFSCar, Rod Washington Luis, KM 235, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Gerontol, Sao Carlos - Brazil

^[3] Univ Santa Cruz do Sul, Dept Phys Educ & Hlth, Santa Cruz Do Sul, RS - Brazil

^[4] Univ Fed Sao Carlos, Dept Med, Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 10, n. 1 MAR 9 2020.
• Citações Web of Science: 0

Resumo

Our aim was to identify optimal cardiopulmonary exercise testing (CPET) threshold values that distinguish disease severity progression in patients with co-existing systolic heart failure (HF) and chronic obstructive pulmonary disease (COPD), and to evaluate the impact of the cut-off determined on the prognosis of hospitalizations. We evaluated 40 patients (30 men and 10 woman) with HF and COPD through pulmonary function testing, doppler echocardiography and maximal incremental CPET on a cycle ergometer. Several significant CPET threshold values were identified in detecting a forced expiratory volume in 1second (FEV1) < 1.6L: 1) oxygen uptake efficiency slope (OUES) < 1.3; and 2) circulatory power (CP) < 2383mmHg.mlO(2).kg(-1). CPET significant threshold values in identifying a left ventricular ejection fraction (LVEF) < 39% were: 1) OUES: < 1.3; 2) CP < 2116mmHg.mlO(2).kg(-1).min(-1) and minute ventilation/carbon dioxide production (V.(E)/V.CO2) slope>38. The 15 (38%) patients hospitalized during follow-up (8 +/- 2 months). In the hospitalizations analysis, LVEF < 39% and FEV1 < 1.6, OUES < 1.3, CP<2116mmHg.mlO(2).kg(-1).min(-1) and V.(E)/V.CO2>38 were a strong risk predictor for hospitalization (P <= 0.050). The CPET response effectively identified worsening disease severity in patients with a HF-COPD phenotype. LVEF, FEV1, CP, OUES, and the V.(E)/V.CO2 slope may be particularly useful in the clinical assessment and strong risk predictor for hospitalization. (AU)

• Processo FAPESP: 18/03233-0 - Estudo da interação cardiorrespiratória e da oferta de oxigênio periférica e cerebral como moduladores da capacidade de exercício durante a aplicação do binível na coexistência da DPOC-ICC
• Beneficiário: Cássia da Luz Goulart
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 15/26501-1 - Estudo dos fatores limitantes ao exercício físico e efeitos dos recursos adjuntos à reabilitação nas doenças cardiorrespiratórias crônicas: uma abordagem multicêntrica
• Beneficiário: Audrey Borghi Silva
• Modalidade de apoio: Auxílio à Pesquisa - Temático