Vitamin D receptor FokI and BglI genetic polymorphisms, dental caries, and gingivitis

Autor(es)

Barbosa, Mariane C. F. ^[1] ; Lima, Daniela C. ^[1] ; Reis, Caio L. B. ^[1] ; Reis, Ana L. M. ^[1] ; Jr, Darlan Rigo ; Segato, Raquel A. B. ^[2] ; Storrer, Carmen L. M. ^[3] ; Kuchler, Erika C. ^{[2, 3]} ; de Oliveira, Daniela S. B. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Alfenas, Sch Dent, Dept Clin & Surg, Alfenas, MG - Brazil

^[2] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Pediat Dent, Ribeirao Preto - Brazil

^[3] Jr, Jr., Darlan Rigo, Posit Univ, Sch Hlth Sci, Curitiba, Parana - Brazil

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Paediatric Dentistry; v. 30, n. 5, p. 642-649, SEP 2020.
• Citações Web of Science: 1

Resumo

Background \& Aim To investigate the association between the genetic polymorphisms FokI (rs2228570) and BglI (rs739837) in vitamin D receptor (VDR) with dental caries and gingivitis susceptibility. Design This study included 353 Brazilian children (8 to 11 years old). Dental caries was assessed using ICDAS (International System for Detection and Assessment of Carious Lesions) and gingival bleeding using Community Periodontal Index (CPI). The presence of visible biofilm was also evaluated. DNA was extracted from saliva, and real-time PCR was used to evaluate genetic polymorphisms inVDR: rs2228570 (FokI, A>G/Met>Thr) and rs739837 (BglI, G>T). Dental caries was evaluated as a continuous data (mean and standard deviation-SD) and was also categorized (ICDAS(0)versusICDAS(1-6)or ICDAS(1-2)versusICDAS(3-6)). Gingivitis was categorized in with and without. One-way ANOVA was used for comparisons of caries among genotypes. Chi-square test, logistic regression, and haplotype analysis were performed (P < .05). Results Biofilm was associated with dental caries susceptibility and gingivitis (P < .05). The mean distribution of the caries lesions and cavitated caries lesions among FokI and BgII genotypes were not statistically significant (P > .05). Genotype distributions among caries groups (in the two different cut-offs) and among gingivitis and non-gingivitis groups were not statistically significant (P > .05). Conclusion The polymorphisms FokI and BglI inVDRwere not associated with dental caries or gingivitis. (AU)

• Processo FAPESP: 15/06866-5 - Avaliação do papel do estrógeno no desenvolvimento dentofacial
• Beneficiário: Erika Calvano Kuchler
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores