Glucose as an Eco-Friendly Reductant in a One-Pot Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

Autor(es)

dos Santos, Thiago ^{[1, 2]} ; Grundke, Caroline ^[1] ; Lucas, Tobias ^[1] ; Grossmann, Luca ^[1] ; Clososki, Giuliano Cesar ^[2] ; Opatz, Till ^[1]

Afiliação do(s) autor(es)

^[1] Johannes Gutenberg Univ Mainz, Dept Chem, D-55128 Mainz - Germany

^[2] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Biomol Sci, Ave Cafe S-N, BR-14040900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY; AUG 2020.
• Citações Web of Science: 0

Resumo

Carbohydrates such as glucose are an abundant renewable resource that can be employed in synthetic processes as a source of carbon and/or hydrogen to yield products of high economical and biological impact. Herein, we report a versatile and environmentally friendly protocol for the one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones, a privileged scaffold in medicinal chemistry, based on the use of glucose as an eco-friendly reductant in alkaline aqueous medium. This method can be viewed as a blueprint for the development of further one-pot sequences involving glucose as a reductant. (AU)

• Processo FAPESP: 18/14150-8 - Funcionalização seletiva de aromáticos: estudos metodológicos e novas aplicações na síntese de substâncias bioativas
• Beneficiário: Giuliano Cesar Clososki
• Linha de fomento: Auxílio à Pesquisa - Regular