Glucose as an Eco-Friendly Reductant in a One-Pot Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

Author(s)

dos Santos, Thiago ^{[1, 2]} ; Grundke, Caroline ^[1] ; Lucas, Tobias ^[1] ; Grossmann, Luca ^[1] ; Clososki, Giuliano Cesar ^[2] ; Opatz, Till ^[1]

Affiliation

^[1] Johannes Gutenberg Univ Mainz, Dept Chem, D-55128 Mainz - Germany

^[2] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Biomol Sci, Ave Cafe S-N, BR-14040900 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY; v. 2020, n. 41 AUG 2020.
• Web of Science Citations: 0

Abstract

Carbohydrates such as glucose are an abundant renewable resource that can be employed in synthetic processes as a source of carbon and/or hydrogen to yield products of high economical and biological impact. Herein, we report a versatile and environmentally friendly protocol for the one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones, a privileged scaffold in medicinal chemistry, based on the use of glucose as an eco-friendly reductant in alkaline aqueous medium. This method can be viewed as a blueprint for the development of further one-pot sequences involving glucose as a reductant. (AU)

• FAPESP's process: 18/14150-8 - Selective aromatic functionalization: Methodological Studies and new applications in the synthesis of BIOATIVE compounds
• Grantee: Giuliano Cesar Clososki
• Support Opportunities: Regular Research Grants