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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Collagen I and III Ratios and Tenacity of Rats' Muscle Injured and Treated with Platelet-Rich Plasma

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Autor(es):
Garcia, Thiago Alves [1] ; Tamura Ozaki, Guilherme Akio [2] ; Castoldi, Robson Chacon [3] ; Job, Aldo Eloizo [4] ; Trindade Camargo, Regina Celi [5] ; Silva Camargo Filho, Jose Carlos [5] ; Belangero, William Dias [6]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Fac Ciencias Med, Ctr Med Expt & Cirurgia, Lab Biomat LABIMO, Sao Paulo - Brazil
[2] Univ Estadual Paulista UNIP, Dept Fisioterapia, Campus Aracatuba, Sao Paulo - Brazil
[3] Univ Oeste Paulista, Dept Educ Fis, Campus Presidente Prudente, Sao Paulo - Brazil
[4] Univ Estadual Paulista, Dept Fis, Campus Presidente Prudente, Sao Paulo - Brazil
[5] Univ Estadual Paulista, Dept Fisioterapia, Campus Presidente Prudente, Sao Paulo - Brazil
[6] Univ Estadual Campinas, Fac Ciencias, Dept Ortopedia & Traumatol, Sao Paulo - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: INTERNATIONAL JOURNAL OF MORPHOLOGY; v. 38, n. 5, p. 1392-1397, OCT 2020.
Citações Web of Science: 0
Resumo

Severe muscle injuries are common in accidents and have a delayed recovery of muscle integrity. In these cases, muscle suture surgery is the standard treatment. However, Platelet Rich Plasma (PRP), has been widely used in orthopedic injuries due to its growth factors. Thus, the objective of the study will be to analyze the association of suture and PRP techniques in the collagen and tenacity of the injured muscle. Were used seventy rats, divided into five groups: control (C), injury control (CI), injury and suture (IS), injury and PRP (IP), injury, suture, and PRP (ISP). Were sectioned approximately 50 % of the width and 100 % of the thickness of the gastrocnemius muscle. The homologous PRP was applied 24h after the injury. On the 7th day after the injury, the animals were euthanized and their muscles subjected to mechanical testing to measure tenacity or collagen analysis to calculate the ratio between type I and III collagen. The results show a significant decrease (p <0.05) in the values of the relationship between collagens in all injured groups (CI, IS, IP, ISP) compared to group C. In injured groups, the tenacity was significantly (p <0.05) reduced compared to the control group, with no observed difference between treatments and injured groups. The amount of collagen in the injured area has increased, but it did not affect the tenacity of the muscles, which was reduced. (AU)

Processo FAPESP: 17/06930-0 - Análise do tratamento de lesão muscular pela associação da sutura e do plasma rico em plaquetas
Beneficiário:Thiago Alves Garcia
Modalidade de apoio: Bolsas no Brasil - Mestrado