Study of the activity of Punica granatum-mediated silver nanoparticles against Candida albicans and Candida glabrata, alone or in combination with azoles or polyenes

Autor(es)

Santos Souza, Jose Antonio ^[1] ; Alves, Marta M. ^[2] ; Barbosa, Debora Barros ^[3] ; Lopes, Maria Manuel ^[4] ; Pinto, Eugenia ^{[5, 6]} ; Figueiral, Maria Helena ^[7] ; Delbem, Alberto Carlos B. ^[1] ; Mira, Nuno Pereira ^[8]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ Unesp, Sch Dent Aracatuba, Dept Pediat Dent & Publ Hlth, Aracatuba, SP - Brazil

^[2] Univ Lisbon, Ctr Quim Estrutural, Inst Super Tecn, Lisbon - Portugal

^[3] Sao Paulo State Univ UNESP, Sch Dent Aracatuba, Dept Dent Mat & Prosthodont, Sao Paulo - Brazil

^[4] Univ Lisbon, Dept Microbiol & Imunol, Fac Farm, Av Prof Gama Pinto, P-1649003 Lisbon - Portugal

^[5] Univ Porto, Biol Sci Dept, Lab Microbiol, Fac Pharm, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto - Portugal

^[6] Univ Porto, Interdisciplinary Ctr Marine & Environm Res CIIMA, Ave Gen Norton de Matos, P-4450208 Matosinhos - Portugal

^[7] Univ Porto, Fac Dent, Rua Manuel Pereira da Silva, P-4200392 Porto - Portugal

^[8] Univ Lisbon, Inst Bioengn & Biosci, Inst Super Tecn, iBB, Dept Bioengn, Av Rovisco Pais, P-1049001 Lisbon - Portugal

• Tipo de documento: Artigo Científico
• Fonte: Medical Mycology; v. 58, n. 4, p. 564-567, JUN 2020.
• Citações Web of Science: 0

Resumo

The continuous emergence of Candida strains resistant to currently used antifungals demands the development of new alternatives that could reduce the burden of candidiasis. In this work silver nanoparticles synthesized using a green route are efficiently used, alone or in combination with fluconazole, amphotericin B or nystatine, to inhibit growth of C. albicans and C. glabrata oral clinical strains, including in strains showing resistance to fluconazole. A potent inhibitory effect over biofilm formation prompted by the two Candida species was also observed, including in mature biofilm cells. These results foster the use of phytotherapeutics as effective treatments in oral candidiasis. (AU)

• Processo FAPESP: 16/22039-4 - Análise dos mecanismos moleculares de toxicidade e tolerância de cepas de C. albicans, C. glabrata e S. mutans a nanopartículas de Ag obtidas pela síntese 'green': uma abordagem à escala do genoma
• Beneficiário: José Antonio Santos Souza
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado