Design of chitosan-based particle systems: A review of the physicochemical foundations for tailored properties

Autor(es):Mostrar menos -

Ferreira, Leonardo M. B. ^[1] ; dos Santos, Aline M. ^[2] ; Boni, Fernanda Isadora ^[2] ; dos Santos, Karen C. ^[2] ; Robusti, Leda M. Gorla ^[2] ; de Souza, Mauricio P. C. ^[2] ; Ferreira, Natalia N. ^[2] ; Carvalho, Suzana G. ^[2] ; Cardoso, Valera M. O. ^[2] ; Chorilli, Marlus ^[2] ; Cury, Beatriz S. F. ^[2] ; de Godoi, Denis R. M. ^[3] ; Gremiao, Maria Palmira D. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sao Carlos Inst Phys, Grp Nanomed & Nanotoxicol, BR-13566590 Sao Carlos - Brazil

^[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Pharmaceut, BR-14800903 Araraquara, SP - Brazil

^[3] Sao Paulo State Univ UNESP, Inst Chem Araraquara, Dept Physicochem, BR-14800060 Araraquara, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Carbohydrate Polymers; v. 250, DEC 15 2020.
• Citações Web of Science: 0

Resumo

Chitosan-based particles are widely proposed as biocompatible drug delivery systems with mucoadhesive and permeation enhancing properties. However, strategies on how to modulate the intended biological responses are still scarce. Considering that particle properties affect the biological outcome, the rational design of the synthesis variables should be proposed to engineer drug delivery systems with improved biological performance. The purpose of this review is to establish a deeper understanding of possible correlations between these variables and the particle properties from theoretical and experimental perspectives. The fundamental physicochemical knowledge of chitosan-based polyelectrolyte complexation and surface modification is discussed focusing on chitosan-TPP, polyelectrolyte complexes, and chitosan-surface modified PLGA or lipid particles. A set of design considerations is proposed to enable future investigation in the development of chitosan particles with modulated properties. The approach presented here contributes to the rational design of chitosan-based particles that meet different requirements for biological activities. (AU)

• Processo FAPESP: 17/16324-0 - Sistemas com propriedades mucoadesivas para a liberação de fármacos na mucosa intestinal
• Beneficiário: Maria Palmira Daflon Gremião
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/50928-2 - INCT 2014: Nanotecnologia Farmacêutica: uma abordagem transdisciplinar
• Beneficiário: Maria Vitória Lopes Badra Bentley
• Modalidade de apoio: Auxílio à Pesquisa - Temático