Nanotechnological strategies for systemic microbial infections treatment: A review

Autor(es)

dos Santos Ramos, Matheus Aparecido ^[1] ; dos Santos, Karen Cristina ^[1] ; da Silva, Patricia Bento ^[2] ; de Toledo, Luciani Gaspar ^[3] ; Marena, Gabriel Davi ^[1] ; Rodero, Camila Fernanda ^[1] ; Furquim de Camargo, Bruna Almeida ^[3] ; Fortunato, Giovanna Capaldi ^[3] ; Bauab, Tais Maria ^[3] ; Chorilli, Marlus ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, Campus Araraquara, BR-14800903 Araraquara, SP - Brazil

^[2] Brasilia Univ UNB, Inst Biol Sci, Dept Genet & Morphol, BR-70735100 Brasilia, DF - Brazil

^[3] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Biol Sci, Campus Araraquara, BR-1480903 Araraquara, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: International Journal of Pharmaceutics; v. 589, NOV 15 2020.
• Citações Web of Science: 5

Resumo

Systemic infections is one of the major causes of mortality worldwide, and a shortage of drug approaches applied for the rapid and necessary treatment contribute to increase the levels of death in affected patients. Several drug delivery systems based in nanotechnology such as metallic nanoparticles, liposomes, nanoemulsion, micro emulsion, polymeric nanoparticles, solid lipid nanoparticles, dendrimers, hydrogels and liquid crystals can contribute in the biological performance of active substances for the treatment of microbial diseases triggered by fungi, bacteria, virus and parasites. In the presentation of these statements, this review article present and demonstrate the effectiveness of these drug delivery systems for the treatment of systemic diseases caused by several microorganisms, through a review of studies on scientific literature worldwide that contributes to better information for the most diverse professionals from the areas of health sciences. The studies demonstrated that the drug delivery systems described can contribute to the therapeutic scenario of these diseases, being classified as safe, active platforms and with therapeutic versatility. (AU)

• Processo FAPESP: 14/50928-2 - INCT 2014: Nanotecnologia Farmacêutica: uma abordagem transdisciplinar
• Beneficiário: Maria Vitória Lopes Badra Bentley
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/23442-2 - Avaliação do potencial de lipossomas para co-encapsulação de anfotericina B e micafungina no tratamento de infecção sistêmica causada por Candida auris
• Beneficiário: Matheus Aparecido dos Santos Ramos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado