Role of Melatonin in the Synchronization of Asexual Forms in the Parasite Plasmodium falciparum

Autor(es)

Singh, Maneesh Kumar ^[1] ; de Menezes Dias, Barbara Karina ^[2] ; Garcia, Celia R. S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, BR-05508000 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, BR-05508000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: BIOMOLECULES; v. 10, n. 9 SEP 2020.
• Citações Web of Science: 1

Resumo

The indoleamine compound melatonin has been extensively studied in the regulation of the circadian rhythm in nearly all vertebrates. The effects of melatonin have also been studied in Protozoan parasites, especially in the synchronization of the human malaria parasitePlasmodium falciparumvia a complex downstream signalling pathway. Melatonin activates protein kinase A (PfPKA) and requires the activation of protein kinase 7 (PfPK7), PLC-IP3, and a subset of genes from the ubiquitin-proteasome system. In other parasites, such asTrypanosoma cruziandToxoplasma gondii, melatonin increases inflammatory components, thus amplifying the protective response of the host's immune system and affecting parasite load. The development of melatonin-related indole compounds exhibiting antiparasitic properties clearly suggests this new and effective approach as an alternative treatment. Therefore, it is critical to understand how melatonin confers stimulatory functions in host-parasite biology. (AU)

• Processo FAPESP: 17/08684-7 - Decodificar aspectos da biologia celular e molecular do Plasmodium como uma ferramenta para desenvolver novos antimaláricos
• Beneficiário: Célia Regina da Silva Garcia
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/09490-7 - Triagem de ligantes para PfSR1, um provável receptor tipo GPCR, e identificação de um possível receptor de IP3 na sinalização de cálcio no Plasmodium falciparum
• Beneficiário: Maneesh Kumar Singh
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado