| Texto completo | |
| Autor(es): |
Sidarta-Oliveira, Davi
[1, 2]
;
Jara, Carlos Poblete
[1, 3]
;
Ferruzzi, Adriano J.
[4, 5]
;
Skaf, Munir S.
[4, 5]
;
Velander, William H.
[6]
;
Araujo, Eliana P.
[1, 3]
;
Velloso, Licio A.
[1]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Campinas, Inst Biol, Obes & Comorbid Res Ctr, Lab Cell Signaling, Bloco Z, Campus Univ Zeferino Vaz, BR-13083864 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Med Sci, Phys Scientist Grad Program, Campinas - Brazil
[3] Univ Estadual Campinas, Nursing Sch, Campinas - Brazil
[4] Univ Estadual Campinas, Inst Chem, Campinas - Brazil
[5] Univ Estadual Campinas, Ctr Comp Engn & Sci, Campinas - Brazil
[6] Univ Nebraska, Dept Chem & Biomol Engn, Lincoln, NE 68583 - USA
Número total de Afiliações: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | SCIENTIFIC REPORTS; v. 10, n. 1 NOV 11 2020. |
| Citações Web of Science: | 12 |
| Resumo | |
SARS-CoV-2, the pathogenic agent of COVID-19, employs angiotensin converting enzyme-2 (ACE2) as its cell entry receptor. Clinical data reveal that in severe COVID-19, SARS-CoV-2 infects the lung, leading to a frequently lethal triad of respiratory insufficiency, acute cardiovascular failure, and coagulopathy. Physiologically, ACE2 plays a role in the regulation of three systems that could potentially be involved in the pathogenesis of severe COVID-19: the kinin-kallikrein system, resulting in acute lung inflammatory edema; the renin-angiotensin system, promoting cardiovascular instability; and the coagulation system, leading to thromboembolism. Here we assembled a healthy human lung cell atlas meta-analysis with similar to 130,000 public single-cell transcriptomes and show that key elements of the bradykinin, angiotensin and coagulation systems are co-expressed with ACE2 in alveolar cells and associated with their differentiation dynamics, which could explain how changes in ACE2 promoted by SARS-CoV-2 cell entry result in the development of the three most severe clinical components of COVID-19. (AU) | |
| Processo FAPESP: | 13/08293-7 - CECC - Centro de Engenharia e Ciências Computacionais |
| Beneficiário: | Munir Salomao Skaf |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |
| Processo FAPESP: | 13/07607-8 - CMPO - Centro Multidisciplinar de Pesquisa em Obesidade e Doenças Associadas |
| Beneficiário: | Licio Augusto Velloso |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |